胎儿酒精谱系障碍筛查工具：系统评价。
Fetal alcohol spectrum disorders screening tools: A systematic review.
机构信息
Telethon Kids Institute, P.O. Box 855, West Perth, Western Australia 6872, Australia.
Telethon Kids Institute, P.O. Box 855, West Perth, Western Australia 6872, Australia.
出版信息
Res Dev Disabil. 2022 Mar;122:104168. doi: 10.1016/j.ridd.2021.104168. Epub 2022 Jan 4.
BACKGROUND
Screening facilitates the early identification of fetal alcohol spectrum disorder (FASD) and prevalence estimation of FASD for timely prevention, diagnostic, and management planning. However, little is known about FASD screening tools.
AIMS
The aims of this systematic review are to identify FASD screening tools and examine their performance characteristics.
METHODS
Four electronic databases were searched for eligible studies that examined individuals with FASD or prenatal alcohol exposure and reported the sensitivity and specificity of FASD screening tools. The quality of the studies was assessed using the Quality Assessment of Diagnostic Studies-2 tool.
RESULTS
Sixteen studies were identified, comprising five fetal alcohol syndrome (FAS) and seven FASD screening tools. They varied in screening approach and performance characteristics and were linked to four different diagnostic criteria. FAS screening tools performed well in the identification of individuals at risk of FAS while the performance of FASD screening tools varied in the identification of individuals at risk of FASD.
CONCLUSION AND IMPLICATIONS
Results highlight the vast differences in the screening approaches performance characteristics, and diagnostic criteria linked to FASD screening tools. More research is needed to identify biomarkers unique to FASD to guide the development of accurate FASD screening tools.
背景
筛查有助于早期识别胎儿酒精谱系障碍（FASD），并估算 FASD 的流行率，以便及时进行预防、诊断和管理规划。然而，人们对 FASD 筛查工具知之甚少。
目的
本系统评价旨在确定 FASD 筛查工具，并研究其性能特征。
方法
在四个电子数据库中搜索了合格的研究，这些研究调查了患有 FASD 或产前酒精暴露的个体，并报告了 FASD 筛查工具的敏感性和特异性。使用诊断研究质量评估工具-2 对研究质量进行了评估。
结果
确定了 16 项研究，包括 5 项胎儿酒精综合征（FAS）和 7 项 FASD 筛查工具。它们在筛查方法和性能特征上存在差异，并与四个不同的诊断标准相关联。FAS 筛查工具在识别有患 FAS 风险的个体方面表现良好，而 FASD 筛查工具在识别有患 FASD 风险的个体方面的表现则有所不同。
结论和意义
结果突出了 FASD 筛查工具在筛查方法、性能特征和与 FASD 筛查工具相关的诊断标准方面的巨大差异。需要进一步研究来确定 FASD 特有的生物标志物，以指导开发准确的 FASD 筛查工具。
Zotero 插件