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T4-6 段胸段脊柱结核一期后路单纯手术治疗的疗效分析:5 年以上随访结果

Efficacy analysis of one-stage posterior-only surgical treatment for thoracic spinal tuberculosis in the T4-6 segments with minimum 5-year follow-up.

机构信息

Department of Spine Surgery, Xi'an Jiaotong University College of Medicine, Honghui Hospital, Xi'an, 710054, Shaanxi, China.

Shaanxi University of Chinese Medicine, Xi'an, 712046, China.

出版信息

Sci Rep. 2022 Jan 7;12(1):149. doi: 10.1038/s41598-021-04138-2.

Abstract

In recent years, with the in-depth research on spinal tuberculosis, posterior surgery alone has been praised highly by more and more surgeons due to the better correction of kyphosis, better maintenance of spinal physiological curvature, smaller surgical trauma and fewer surgical complications. However, there is currently lack of relevant reports about the efficacy of posterior surgery alone in the treatment of tuberculosis in the T4-6 segments. This study aimed to evaluate the clinical study efficacy and feasibility of one-stage posterior-only surgical treatment for thoracic spinal tuberculosis in the T4-6 segments. 67 patients with tuberculosis in T4-6 segments who underwent one-stage posterior-only surgery were included in this study. The clinical efficacy was evaluated using statistical analysis based on the data about erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Oswestry Dability Index (ODI) score, Visual Analogue Scale (VAS) score and Cobb angle before surgery, after surgery and at the last follow-up. All patients completed fusion during the follow-up period of 6-9 months. ESR and CRP were returned to normal for all patients at 6 months follow-up. In the meanwhile, among the 27 patients combined with neurological impairment, neurological functions of 22 cases (81.48%) recovered completely at the last follow-up (P < 0.05). Cobb angle of the kyphosis was improved from preoperative 34.8 ± 10.9° to postoperative 9.6 ± 2.8°, maintaining at 11.3 ± 3.2° at the last follow-up, The ODI and VAS scores were improved by 77.10% and 81.70%, respectively. This 5-year follow-up study shows that better clinical efficacy can be achieved for tuberculosis in T4-6 segments using one-stage posterior-only approach by costotransverse debridement in combination with bone graft and internal fixation. The posterior surgical method cannot only effectively accomplish debridement, obtain satisfactory clinical results, but also well correct kyphotic deformity and maintain it.

摘要

近年来,随着对脊柱结核的深入研究,单纯后路手术由于能更好地矫正后凸畸形、更好地维持脊柱生理曲度、手术创伤小、手术并发症少,越来越受到外科医生的青睐。但是,目前对于 T4-6 段脊柱结核单纯后路手术的疗效尚缺乏相关报道。本研究旨在评估 T4-6 段胸段脊柱结核一期后路单纯手术治疗的临床疗效和可行性。

本研究纳入 67 例 T4-6 段结核患者,均采用一期后路单纯手术治疗。通过对术前、术后及末次随访时红细胞沉降率(ESR)、C 反应蛋白(CRP)、Oswestry 功能障碍指数(ODI)评分、视觉模拟评分(VAS)评分和 Cobb 角等数据的统计学分析,评估临床疗效。所有患者在 6-9 个月的随访期间均完成融合。所有患者在术后 6 个月 ESR 和 CRP 均恢复正常。同时,27 例合并神经损伤的患者中,22 例(81.48%)神经功能在末次随访时完全恢复(P<0.05)。后凸畸形 Cobb 角由术前的 34.8°±10.9°改善至术后的 9.6°±2.8°,末次随访时维持在 11.3°±3.2°,ODI 和 VAS 评分分别改善了 77.10%和 81.70%。本 5 年随访研究表明,经 Costotransverse 清创术联合植骨和内固定的一期后路单纯手术治疗 T4-6 段结核可获得更好的临床疗效。后路手术方法不仅能有效清创,获得满意的临床效果,而且能很好地矫正后凸畸形并维持。

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