Trambert J J, Bron K M, Zajko A B, Starzl T E, Iwatsuki S
Department of Radiology, Presbyterian University Hospital, Pittsburgh, PA 15213.
AJR Am J Roentgenol. 1987 Nov;149(5):945-8. doi: 10.2214/ajr.149.5.945.
Between February 1981 and June 1984, 15 patients with benign biliary strictures were treated with percutaneous transhepatic balloon dilatation. Three of these patients had received liver transplants. The treatment began with a course of balloon dilatation therapy, after which a stent catheter was left across the stricture. Six weeks later, after duct patency had been shown by cholangiography, the stent catheter was removed from all but two patients, both of whom had intrahepatic sclerosing cholangitis. After this procedure, six patients (40%), including two liver-transplant patients, were stricture-free after one treatment for periods ranging from 27 to 56 months, and were considered to be treatment successes. Nine patients (60%) suffered stricture recurrences. In eight of these patients, the stricture was heralded by symptoms of either cholangitis or jaundice; in one patient, who was on permanent catheter drainage, the stricture was discovered only on follow-up cholangiography. All successfully treated patients had only one stricture, while all patients with more than one stricture suffered recurrences. Our data also suggest a greater responsiveness for anastomotic strictures than for non-anastomotic strictures. Of the patients with recurrences, five had symptom-free intervals of 23 months or more (up to 31 months). The fact that strictures recurred after such long periods of time underscores the importance of long-term follow-up. In view of the number of patients helped, the favorable experience with post-liver-transplantation strictures, and the lack of any major complications in our series, percutaneous biliary balloon dilatation offers a viable alternative to surgical management of benign biliary strictures.
1981年2月至1984年6月期间,15例良性胆管狭窄患者接受了经皮肝穿刺球囊扩张治疗。其中3例患者接受过肝移植。治疗开始时先进行一个疗程的球囊扩张治疗,之后在狭窄处留置一根支架导管。六周后,经胆管造影显示胆管通畅,除两名患有肝内硬化性胆管炎的患者外,其他患者的支架导管均被移除。此操作后,6例患者(40%),包括2例肝移植患者,经一次治疗后狭窄解除,时间长达27至56个月,被视为治疗成功。9例患者(60%)出现狭窄复发。其中8例患者的狭窄复发前出现胆管炎或黄疸症状;1例长期接受导管引流的患者,仅在随访胆管造影时发现狭窄复发。所有成功治疗的患者仅有一处狭窄,而所有有多处长狭窄的患者均出现复发。我们的数据还表明,吻合口狭窄比非吻合口狭窄对治疗的反应性更高。在复发的患者中,5例患者有23个月或更长时间(最长达31个月)的无症状期。狭窄在如此长的时间后复发这一事实凸显了长期随访的重要性。鉴于得到帮助的患者数量、肝移植后狭窄的良好治疗经验以及我们系列研究中无任何重大并发症,经皮胆管球囊扩张为良性胆管狭窄的手术治疗提供了一种可行的替代方法。