Sunahara F A, Farewell J, Mintz L, Johnson W H
Department of Pharmacology, University of Toronto, Ontario, Canada.
Aviat Space Environ Med. 1987 Sep;58(9 Pt 2):A270-6.
Motion sickness (MS) was provoked in healthy volunteers subjected to simultaneous rotation through the vertical axis with head movements (HM). Arterial blood pressure (BP), heart rate (HR) and forearm blood flows (BF) were intermittently monitored. Forearm BF was measured by venous occluding plethysmography. Rotation at 20 rpm and cyclic HM were continued for 10 min or until the subject requested cessation of HM because of imminent emesis. There were no consistent changes in BP or HR, but marked increases in BF were observed with MS. There was an inverse correlation between duration of HM tolerance and increments in BF. Antimotion sickness medications scopolamine:d-amphetamine (0.4:5.0 mg) or promethazine:ephedrine (25:60 mg) failed to significantly increase the duration of HM; the latter mixture, however, did significantly reduce the HM-induced-hyperemic responses. Administration of naproxyn (275 or 550 mg) did not significantly alter HM duration or BF responses. These studies suggest that BF changes may be an objective index of MS susceptibility.
通过让健康志愿者在垂直轴上同时旋转并伴有头部运动（HM）来诱发晕动病（MS）。间歇性监测动脉血压（BP）、心率（HR）和前臂血流量（BF）。前臂BF通过静脉阻塞体积描记法测量。以20转/分钟的速度旋转并进行周期性HM，持续10分钟，或者直到受试者因即将呕吐而要求停止HM。BP或HR没有一致的变化，但在MS患者中观察到BF显著增加。HM耐受持续时间与BF增加之间存在负相关。抗晕动病药物东莨菪碱：右旋苯丙胺（0.4:5.0毫克）或异丙嗪：麻黄碱（25:60毫克）未能显著增加HM的持续时间；然而，后一种混合物确实显著降低了HM诱导的充血反应。服用萘普生（275或550毫克）并未显著改变HM持续时间或BF反应。这些研究表明，BF变化可能是MS易感性的一个客观指标。
