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[成瘾性吸入剂——对肺部的一项挑战]

[Addictive inhalants-A challenge for the lungs].

作者信息

Bauer-Kemény Claudia, Kreuter Michael

机构信息

Pneumologie und Beatmungsmedizin, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126 Heidelberg, Deutschland.

Deutsches Zentrum für Lungenforschung Heidelberg, Heidelberg, Deutschland.

出版信息

Pneumologe (Berl). 2022;19(1):49-59. doi: 10.1007/s10405-021-00428-8. Epub 2022 Jan 4.

DOI:10.1007/s10405-021-00428-8
PMID:35002591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8724664/
Abstract

The use of inhaled psychotropic substances is widespread in our society. In addition to the wide variety of tobacco-containing smoking products, e‑cigarettes, cannabis, sniffing substances, cocaine and heroin are consumed by inhalation. While the harmful effects of most tobacco-containing smoking products on the lungs have been sufficiently researched, there is still a lack of scientifically sound evidence for many other substances consumed by inhalation. In particular, for novel products, such as e‑cigarettes and tobacco heaters, there is a lack of independent standardized data demonstrating reduced health risk as a result of lower exposure to harmful substances. Clear conclusions are also currently not possible for the long-term effects of cannabis use on the lungs and respiratory tract. For the inhaled use of cocaine and heroin, on the other hand, considerable damage to the lungs can be documented, especially in the case of extensive and chronic use.

摘要

吸入性精神活性物质在我们的社会中广泛使用。除了种类繁多的含烟草吸烟产品外,电子烟、大麻、嗅吸物质、可卡因和海洛因也通过吸入方式使用。虽然大多数含烟草吸烟产品对肺部的有害影响已得到充分研究,但对于许多其他吸入性物质,仍缺乏科学可靠的证据。特别是对于电子烟和烟草加热装置等新产品,缺乏独立的标准化数据来证明因接触有害物质减少而降低了健康风险。目前对于大麻使用对肺部和呼吸道的长期影响也无法得出明确结论。另一方面,对于可卡因和海洛因的吸入使用,可以证明对肺部有相当大的损害,尤其是在大量和长期使用的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8724664/e451d1371721/10405_2021_428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8724664/a39d9a4fd753/10405_2021_428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8724664/e451d1371721/10405_2021_428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8724664/a39d9a4fd753/10405_2021_428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/8724664/e451d1371721/10405_2021_428_Fig2_HTML.jpg

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本文引用的文献

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Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study.加热不燃烧卷烟慢性使用对氧化应激、内皮功能障碍和血小板激活的影响:SUR-VAPES 慢性研究。
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利用二维斑点追踪超声心动图比较 IQOS(加热不燃烧烟草制品)和香烟对心脏功能的影响。
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Comparison of Nicotine Dependence and Biomarker Levels among Traditional Cigarette, Heat-Not-Burn Cigarette, and Liquid E-Cigarette Users: Results from the Think Study.传统香烟、加热不燃烧香烟和电子烟使用者的尼古丁依赖和生物标志物水平比较:来自 Think 研究的结果。
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Heat-Not-Burn cigarette induces oxidative stress response in primary rat alveolar epithelial cells.加热不燃烧卷烟诱导原代大鼠肺泡上皮细胞氧化应激反应。
PLoS One. 2020 Nov 25;15(11):e0242789. doi: 10.1371/journal.pone.0242789. eCollection 2020.
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Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells.加热烟草制品、电子烟和传统卷烟气溶胶的化学成分比较及其对人支气管上皮BEAS-2B细胞的毒性影响。
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