Department of Food Safety, National Institute of Public Health NIH - National Research Institute, Warsaw, Poland.
Pol J Microbiol. 2021 Dec;70(4):421-429. doi: 10.33073/pjm-2021-040. Epub 2021 Dec 23.
Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation, recombination, or insertion. Silent genes can also be activated in laboratory conditions using pleiotropic, targeted genome-wide, or biosynthetic gene cluster approaches. Like every other gene, silent genes can spread through horizontal gene transfer. Most studies have focused on strains with phenotypic resistance, which is the most common subject. However, to fully understand the mechanism behind the spreading of antibiotic resistance, it is reasonable to study the whole resistome, including silent genes.
沉默基因是指通常不表达或表达水平很低的 DNA 序列。这些基因由于突变、重组或插入而变得活跃。沉默基因也可以在实验室条件下通过多效性、靶向全基因组或生物合成基因簇方法激活。与其他基因一样，沉默基因可以通过水平基因转移传播。大多数研究都集中在具有表型抗性的菌株上，这是最常见的研究对象。然而，为了充分了解抗生素抗性传播的机制，研究整个抗性组，包括沉默基因，是合理的。
