Fialho Andre, Fialho Andrea, Ribeiro Bruno, Malespin Miguel, De Melo Silvio, Schey Ron, Ghali Peter
Internal Medicine: Gastroenterology, South Central Regional Medical Center, Laurel, USA.
Gastroenterology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus. 2023 Jan 21;15(1):e34042. doi: 10.7759/cureus.34042. eCollection 2023 Jan.
Background A possible association between (HP) infection and liver diseases including steatosis is suspected. There is a lack of studies evaluating the association of HP and liver steatosis severity using transient elastography. Aim The aim of this study was to evaluate the frequency and risk factors for liver steatosis measured by transient elastography in patients with or without HP. Methods A total of 484 patients tested for liver steatosis and fibrosis using transient elastography from January 2017 to June 2018 were evaluated. Ninety-one patients who were also tested for infection were included in the study. Transient elastography findings were compared between HP-positive patients and HP-negative patients. Demographic, clinical, and laboratory variables and the presence and severity of liver fibrosis and steatosis were analyzed. Results Patients with HP had a higher frequency of steatosis on transient elastography (86.8% 60.7%, p =0.009). Patients with HP had increased steatosis severity compared to HP-negative patients (mild steatosis 15.8% 7.1%, p=0.037; moderate to severe steatosis 71.1% 53.6%, p=0.015, respectively). In the stepwise multivariate logistic regression analysis, HP infection remained an independent risk factor for steatosis (odds ratio: 4.36, 95% confidence interval: 1.09-14.78; p=0.037). Conclusion Patients with HP had an increased steatosis frequency, and patients with liver steatosis may warrant HP evaluation and treatment.
背景 怀疑幽门螺杆菌（HP）感染与包括脂肪变性在内的肝脏疾病之间可能存在关联。目前缺乏使用瞬时弹性成像评估HP与肝脏脂肪变性严重程度之间关联的研究。目的 本研究的目的是评估有无HP感染的患者中通过瞬时弹性成像测量的肝脏脂肪变性的频率和危险因素。方法 对2017年1月至2018年6月期间共484例使用瞬时弹性成像检测肝脏脂肪变性和纤维化的患者进行评估。其中91例同时检测了HP感染的患者被纳入研究。比较HP阳性患者和HP阴性患者的瞬时弹性成像结果。分析人口统计学、临床和实验室变量以及肝纤维化和脂肪变性的存在及严重程度。结果 HP阳性患者通过瞬时弹性成像检测到的脂肪变性频率更高（86.8%对60.7%，p = 0.009）。与HP阴性患者相比，HP阳性患者的脂肪变性严重程度增加（轻度脂肪变性15.8%对7.1%，p = 0.037；中度至重度脂肪变性71.1%对53.6%，p = 0.015）。在逐步多因素逻辑回归分析中，HP感染仍然是脂肪变性的独立危险因素（优势比：4.36，95%置信区间：1.09 - 14.78；p = 0.037）。结论 HP阳性患者的脂肪变性频率增加，肝脏脂肪变性患者可能需要进行HP评估和治疗。
