Jing Danrong, Xiao Hui, Shen Minxue, Chen Xiang, Han Xi, Kuang Yehong, Zhu Wu, Xiao Yi
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis (Xiangya Hospital), Central South University, Changsha, China.
Front Med (Lausanne). 2021 Dec 24;8:771645. doi: 10.3389/fmed.2021.771645. eCollection 2021.
Patients with psoriasis are prone to suffer from anxiety and depression during their lifetime. This study aimed to investigate the association of psoriasis with anxiety and depression in Chinese patients. A case-control study in Chinese patients with psoriasis vulgaris and healthy controls was conducted. Clinical information based on patient-reported, clinical information, and reliable structured questionnaires were collected. Multivariable logistic regression was used to investigate the associations, in terms of adjusted odds ratios (AORs). We continuously selected 1,571 patients who were firstly diagnosed with psoriasis vulgaris, and 1,571 healthy controls, matched by age and sex. The risk of depression in the psoriasis vulgaris group was higher than that in the healthy controls (AOR = 1.30, = 0.047), while no differences were found in the risk of anxiety between the two groups (AOR = 1.18, = 0.381). Subgroup analysis by disease onsets showed that late-onset psoriasis (LOP) was significantly associated with a higher risk of anxiety (AOR = 1.47, = 0.033) and depression symptoms (AOR = 1.85, = 0.012) but not with early-onset psoriasis (EOP). Subgroup analysis by disease severity indicated that no difference was observed in the associations of mild psoriasis vulgaris, moderate-to-severe psoriasis vulgaris with anxiety and depression. Patients with psoriasis vulgaris were more likely to develop depression compared with the general population. LOP patients were positively associated with anxiety and depression. We believe the screening of emotional disorders should be included in the daily management of psoriasis patients.
银屑病患者在其一生中容易出现焦虑和抑郁情绪。本研究旨在调查中国患者中银屑病与焦虑和抑郁的关联。对中国寻常型银屑病患者和健康对照者进行了一项病例对照研究。收集了基于患者报告的临床信息、临床资料以及可靠的结构化问卷。采用多变量逻辑回归分析来研究这种关联，并计算调整后的优势比（AOR）。我们连续选取了1571例初诊为寻常型银屑病的患者以及1571名年龄和性别相匹配的健康对照者。寻常型银屑病组的抑郁风险高于健康对照组（AOR = 1.30，P = 0.047），而两组之间的焦虑风险无差异（AOR = 1.18，P = 0.381）。按发病情况进行的亚组分析显示，晚发型银屑病（LOP）与较高的焦虑风险（AOR = 1.47，P = 0.033）和抑郁症状风险（AOR = 1.85，P = 0.012）显著相关，但与早发型银屑病（EOP）无关。按疾病严重程度进行的亚组分析表明，轻度寻常型银屑病、中度至重度寻常型银屑病与焦虑和抑郁的关联未观察到差异。与普通人群相比，寻常型银屑病患者更易患抑郁症。LOP患者与焦虑和抑郁呈正相关。我们认为银屑病患者的日常管理应包括对情绪障碍的筛查。
