Mengsteab Paulos Y, Freeman Joseph, Barajaa Mohammed A, Nair Lakshmi S, Laurencin Cato T
Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT 06030, USA.
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health, CT 06030, USA.
Regen Eng Transl Med. 2021 Dec;7(4):524-532. doi: 10.1007/s40883-020-00178-8. Epub 2020 Oct 6.
Anterior cruciate ligament (ACL) injuries are common sports injuries that typically require surgical intervention. Autografts and allografts are used to replace damaged ligaments. The drawbacks of autografts and allografts, which include donor site morbidity and variability in quality, have spurred research in the development of bioengineered ligaments. Herein, the design and development of a cost-effective bench-top 3D braiding machine that fabricates scalable and tunable bioengineered ligaments is described. It was demonstrated that braiding angle and picks per inch can be controlled with the bench-top braiding machine. Pore sizes within the reported range needed for vascularization and bone regeneration are demonstrated. By considering a one-to-one linear relationship between cross-sectional area and peak load, the bench-top braiding machine can theoretically fabricate bioengineered ligaments with a peak load that is 9× greater than the human ACL. This bench-top braiding machine is generalizable to all types of yarns and may be used for regenerative engineering applications.
前交叉韧带（ACL）损伤是常见的运动损伤，通常需要手术干预。自体移植物和异体移植物用于替换受损韧带。自体移植物和异体移植物的缺点，包括供体部位发病率和质量变异性，促使人们对生物工程韧带的开发进行研究。本文描述了一种经济高效的台式3D编织机的设计与开发，该编织机可制造可扩展且可调的生物工程韧带。结果表明，台式编织机可以控制编织角度和每英寸的纬纱数。展示了血管化和骨再生所需的报告范围内的孔径。通过考虑横截面积与峰值负荷之间的一对一线性关系，台式编织机理论上可以制造出峰值负荷比人类ACL大9倍的生物工程韧带。这种台式编织机可推广到所有类型的纱线，并可用于再生工程应用。
