Turgut Burak, Mercan Kadir, Ilhan Nevin, Semih Aydogan Selahattin
Department of Ophthalmology, Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
Department of Ophthalmology, Private Sevgi Hospital, Malatya, Turkey.
Beyoglu Eye J. 2021 Sep 27;6(3):180-184. doi: 10.14744/bej.2021.52533. eCollection 2021.
This study evaluated the serum irisin level of patients with age-related macular degeneration (ARMD) and compared it with that of healthy individuals.
The serum irisin level of 15 healthy controls (Group 1) and 15 dry ARMD patients (Group 2) and 15 wet ARMD patients (Group 3) were measured using the enzyme-linked immunosorbent assay (ELISA) method and compared.
There was no statistically significant difference between the groups in terms of age or gender (p>0.05). The mean serum irisin levels of Group 1, Group 2, and Group 3 were 25.81±24.04 ng/mL, 22.93±19.05 ng/mL, and 12.38±8.16 ng/mL, respectively. Although the mean irisin level in the wet ARMD patients was lower than that of the control and dry ARMD groups, there was no statistically significant difference between the groups (p>0.05).
The results suggest that the serum irisin level in ARMD patients is not different from that of healthy individuals. Studies of larger groups that examine the irisin level in the vitreous and neovascular membranes will further elucidate any role in the pathogenesis of ARMD.
本研究评估了年龄相关性黄斑变性（ARMD）患者的血清鸢尾素水平，并将其与健康个体的血清鸢尾素水平进行比较。
采用酶联免疫吸附测定（ELISA）法测量15名健康对照者（第1组）、15名干性ARMD患者（第2组）和15名湿性ARMD患者（第3组）的血清鸢尾素水平，并进行比较。
各组之间在年龄或性别方面无统计学显著差异（p>0.05）。第1组、第2组和第3组的血清鸢尾素平均水平分别为25.81±24.04 ng/mL、22.93±19.05 ng/mL和12.38±8.16 ng/mL。尽管湿性ARMD患者的鸢尾素平均水平低于对照组和干性ARMD组，但各组之间无统计学显著差异（p>0.05）。
结果表明，ARMD患者的血清鸢尾素水平与健康个体无异。对更大样本组进行玻璃体和新生血管膜中鸢尾素水平的研究，将进一步阐明其在ARMD发病机制中的作用。
