Transcriptional response of -transinfected mosquito cells to dengue virus at early stages of infection.

Mosquito-borne flaviviruses are responsible for viral infections and represent a considerable public health burden. is the principal vector of dengue virus (DENV), therefore understanding the intrinsic virus-host interactions is vital, particularly in the presence of the endosymbiont which blocks virus replication in mosquitoes. Here, we examined the transcriptional response of -transinfected Aag2 cells to DENV infection. We identified differentially expressed immune genes that play a key role in the activation of anti-viral defence such as the Toll and immune deficiency pathways. Further, genes encoding cytosine and N-adenosine methyltransferases and SUMOylation, involved in post-transcriptional modifications, an antioxidant enzyme, and heat-shock response were up-regulated at the early stages of DENV infection and are reported here for the first time. Additionally, several long non-coding RNAs were among the differentially regulated genes. Our results provide insight into -transinfected 's initial virus recognition and transcriptional response to DENV infection.