Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Appl Bio Mater. 2021 May 17;4(5):3863-3879. doi: 10.1021/acsabm.0c01247. Epub 2020 Nov 19.
Infectious diseases have become a severe global public health problem. Timely and accurate diagnosis of infected individuals is the key step to control the spread of infectious diseases. Nanosensors that combine the advantages of nanomaterials and biosensing technology have been utilized for sensitive, selective, and rapid disease diagnosis and gained great attention within the chemistry, biology, and medical communities. This review presents a broad overview of a wide range of nanosensors for diagnosis of infectious diseases using different methodologies. We also outline point-of-care nanosensing methods and discuss their use in pathogen detection. This review concludes with challenges and opportunities for diagnosis of infectious diseases using nanosensors.
传染病已成为严重的全球公共卫生问题。及时、准确地诊断感染者是控制传染病传播的关键步骤。将纳米材料的优势与生物传感技术相结合的纳米传感器已被用于敏感、选择性和快速的疾病诊断,并在化学、生物学和医学界引起了广泛关注。本综述广泛概述了使用不同方法学的用于传染病诊断的各种纳米传感器。我们还概述了即时检测纳米传感方法,并讨论了它们在病原体检测中的应用。本综述最后讨论了使用纳米传感器诊断传染病的挑战和机遇。