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纳米材料的进展及其在用于传染病诊断的即时检测(POC)设备中的应用。

Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases.

作者信息

Tram Dai Thien Nhan, Wang Hao, Sugiarto Sigit, Li Tao, Ang Wee Han, Lee Chengkuo, Pastorin Giorgia

机构信息

Pharmacy Department National University of Singapore, Singapore 117543, Singapore.

Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering, Drive 3, Singapore 117576, Singapore.

出版信息

Biotechnol Adv. 2016 Dec;34(8):1275-1288. doi: 10.1016/j.biotechadv.2016.09.003. Epub 2016 Sep 26.

Abstract

Nanotechnology has gained much attention over the last decades, as it offers unique opportunities for the advancement of the next generation of sensing tools. Point-of-care (POC) devices for the selective detection of biomolecules using engineered nanoparticles have become a main research thrust in the diagnostic field. This review presents an overview on how the POC-associated nanotechnology, currently applied for the identification of nucleic acids, proteins and antibodies, might be further exploited for the detection of infectious pathogens: although still premature, future integrations of nanoparticles with biological markers that target specific microorganisms will enable timely therapeutic intervention against life-threatening infectious diseases.

摘要

在过去几十年里,纳米技术备受关注,因为它为下一代传感工具的发展提供了独特机遇。利用工程化纳米颗粒进行生物分子选择性检测的即时检测(POC)设备已成为诊断领域的一个主要研究方向。本综述概述了目前用于核酸、蛋白质和抗体识别的与即时检测相关的纳米技术如何能进一步用于检测传染性病原体:尽管仍不成熟,但纳米颗粒与靶向特定微生物的生物标志物的未来整合将能够针对危及生命的传染病进行及时的治疗干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efe6/7127209/602fbf851666/gr1.jpg

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