Ponce Concepcion, Padilla Philip Ian
Department of Chemistry, College of Arts and Sciences, University of the Philippines, Visayas, Miag-ao, Iloilo, Philippines.
Front Biosci (Elite Ed). 2012 Jan 1;4(1):101-10. doi: 10.2741/e362.
The successful use of the nanoscale-dependent properties of nanomaterials on infectious diseases diagnostics devices lies on a well-engineered surface of both the probes and the transducer. Engineering probe and transducer surfaces involve functionalization of nanomaterials, conjugation to biorecognition elements and nanopatterning. This review presents the most common and most promising functional groups, bioconjugation schemes and patterning strategies of nanomaterials on sensing devices and their specific application to infectious pathogen detection.
纳米材料的纳米级相关特性在传染病诊断设备上的成功应用取决于精心设计的探针和换能器表面。对探针和换能器表面进行工程设计涉及纳米材料的功能化、与生物识别元件的结合以及纳米图案化。本文综述了传感设备上纳米材料最常见且最具前景的官能团、生物共轭方案和图案化策略,以及它们在传染性病原体检测中的具体应用。