Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga 4710-057, Portugal.
IB-S - Institute for Research and Innovation on Bio-Sustainability, University of Minho, Braga 4710-057, Portugal.
ACS Appl Bio Mater. 2021 Aug 16;4(8):5839-5870. doi: 10.1021/acsabm.1c00440. Epub 2021 Jul 18.
Precisely engineered magnetic nanoparticles (MNPs) have been widely explored for applications including theragnostic platforms, drug delivery systems, biomaterial/device coatings, tissue engineering scaffolds, performance-enhanced therapeutic alternatives, and even in SARS-CoV-2 detection strips. Such popularity is due to their unique, challenging, and tailorable physicochemical/magnetic properties. Given the wide biomedical-related potential applications of MNPs, significant achievements have been reached and published (exponentially) in the last five years, both in synthesis and application tailoring. Within this review, and in addition to essential works in this field, we have focused on the latest representative reports regarding the biomedical use of MNPs including characteristics related to their oriented synthesis, tailored geometry, and designed multibiofunctionality. Further, actual trends, needs, and limitations of magnetic-based nanostructures for biomedical applications will also be discussed.
经过精确设计的磁性纳米颗粒（MNPs）已广泛应用于各种领域，包括诊断和治疗平台、药物输送系统、生物材料/设备涂层、组织工程支架、增强治疗效果的替代方法，甚至在 SARS-CoV-2 检测条中也有应用。MNPs 之所以如此受欢迎，是因为其具有独特、具有挑战性且可定制的物理化学/磁性能。鉴于 MNPs 在生物医学方面具有广泛的应用潜力，过去五年中，在合成和应用定制方面已经取得了显著的成就（呈指数级增长），并发表了大量相关研究。在本篇综述中，除了该领域的重要研究工作外，我们还重点介绍了最新的关于 MNPs 在生物医学方面应用的代表性报告，包括与定向合成、定制几何形状和设计多功能性相关的特性。此外，还将讨论基于磁性的纳米结构在生物医学应用中的实际趋势、需求和局限性。
