Cardoso Vanessa Fernandes, Francesko António, Ribeiro Clarisse, Bañobre-López Manuel, Martins Pedro, Lanceros-Mendez Senentxu
Centro de Física, Universidade do Minho, 4710-057, Braga, Portugal.
MEMS-Microelectromechanical Systems Research Unit, Universidade do Minho, 4800-058, Guimarães, Portugal.
Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700845. Epub 2017 Dec 27.
Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.
磁性纳米粒子（NPs）因其独特的化学和物理性质，正在成为热疗、药物释放、组织工程、诊疗一体化和芯片实验室等领域重要的一类生物医学功能纳米材料。尽管可以找到一些综述磁性纳米粒子在生物医学工程领域主要应用的文献，但从合成到表面功能化策略，磁性纳米粒子研究最近取得了快速且显著的进展，这就需要有一篇文献对该研究领域当前的方向和正在取得的进展进行收录、总结和探讨。因此，本论文阐述了磁性纳米粒子的结构、合成、性质以及其在纳米复合材料中的应用，重点介绍了合成过程对磁性纳米粒子磁性和结构性质的最相关影响，以及这些影响如何限制了它们在生物医学领域的应用。此外，本综述接下来将聚焦于磁性纳米粒子在生物医学领域的应用。最后，对使用磁性纳米粒子进行先进生物医学应用的主要挑战进行了讨论，并对未来发展前景进行了批判性展望。
