对具有抗微生物药物耐药性和毒力基因的复杂基因组进行分析。
Genome Analysis of Complex for Antimicrobial Resistance and Virulence Genes.
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0218321. doi: 10.1128/aac.02183-21. Epub 2022 Jan 10.
Abstract
Klebsiella oxytoca complex comprises nine closely related species causing human infections. We curated genomes labeled Klebsiella ( = 14,256) in GenBank and identified 588 belonging to the complex, which were examined for precise species, sequence types, K- and O-antigen types, and virulence and antimicrobial resistance genes. The complex and Klebsiella pneumoniae share many K- and O-antigen types. Of the complex, K. oxytoca and Klebsiella michiganensis appear to carry more virulence genes and be more commonly associated with human infections.
摘要
产酸克雷伯菌复合体包含 9 种密切相关的种，可引起人类感染。我们在 GenBank 中整理了标记为克雷伯氏菌（ = 14256）的基因组，鉴定出属于该复合体的 588 个基因组，对其进行了精确的种属、序列型、K 抗原和 O 抗原型以及毒力和抗微生物药物耐药性基因分析。该复合体与肺炎克雷伯菌共享许多 K 抗原和 O 抗原型。在该复合体中，产酸克雷伯菌和密歇根克雷伯菌似乎携带更多的毒力基因，并且更常与人类感染有关。
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