• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对具有抗微生物药物耐药性和毒力基因的复杂基因组进行分析。

Genome Analysis of Complex for Antimicrobial Resistance and Virulence Genes.

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0218321. doi: 10.1128/aac.02183-21. Epub 2022 Jan 10.

DOI:10.1128/aac.02183-21
PMID:35007133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8923205/
Abstract

Klebsiella oxytoca complex comprises nine closely related species causing human infections. We curated genomes labeled Klebsiella ( = 14,256) in GenBank and identified 588 belonging to the complex, which were examined for precise species, sequence types, K- and O-antigen types, and virulence and antimicrobial resistance genes. The complex and Klebsiella pneumoniae share many K- and O-antigen types. Of the complex, K. oxytoca and Klebsiella michiganensis appear to carry more virulence genes and be more commonly associated with human infections.

摘要

产酸克雷伯菌复合体包含 9 种密切相关的种，可引起人类感染。我们在 GenBank 中整理了标记为克雷伯氏菌（ = 14256）的基因组，鉴定出属于该复合体的 588 个基因组，对其进行了精确的种属、序列型、K 抗原和 O 抗原型以及毒力和抗微生物药物耐药性基因分析。该复合体与肺炎克雷伯菌共享许多 K 抗原和 O 抗原型。在该复合体中，产酸克雷伯菌和密歇根克雷伯菌似乎携带更多的毒力基因，并且更常与人类感染有关。

相似文献

1
Genome Analysis of Complex for Antimicrobial Resistance and Virulence Genes.对具有抗微生物药物耐药性和毒力基因的复杂基因组进行分析。
Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0218321. doi: 10.1128/aac.02183-21. Epub 2022 Jan 10.
2
Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.产酸克雷伯菌复合体：分类学、抗菌耐药性和毒力的最新研究进展。
Clin Microbiol Rev. 2022 Jan 19;35(1):e0000621. doi: 10.1128/CMR.00006-21. Epub 2021 Dec 1.
3
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study.基于全基因组序列信息的 MALDI-TOF MS 诊断揭示了产酸克雷伯菌在侵袭性感染中的重要性：一项回顾性临床研究。
Genome Med. 2021 Sep 13;13(1):150. doi: 10.1186/s13073-021-00960-5.
4
Phylogenetic relationships, virulence and antimicrobial resistance properties of Klebsiella sp. isolated from pet turtles in Korea.从韩国宠物龟中分离出的克氏杆菌的系统发育关系、毒力和抗菌耐药性特征。
Lett Appl Microbiol. 2020 Feb;70(2):71-78. doi: 10.1111/lam.13245. Epub 2019 Nov 28.
5
Emergence of ArmA, a 16S rRNA methylase in highly aminoglycoside-resistant clinical isolates of Klebsiella pneumoniae and Klebsiella oxytoca in Okinawa, Japan.在日本冲绳发现的高度耐氨基糖苷类药物的肺炎克雷伯菌和产酸克雷伯菌临床分离株中出现了 ArmA 16S rRNA 甲基酶。
J Infect Chemother. 2018 Jan;24(1):68-70. doi: 10.1016/j.jiac.2017.09.006. Epub 2017 Oct 21.
6
Multicenter comparative genomic study of Klebsiella oxytoca complex reveals a highly antibiotic-resistant subspecies of Klebsiellamichiganensis.多中心比较基因组学研究表明，产酸克雷伯菌复合体中存在一种高度耐药的肺炎克雷伯菌亚种。
J Microbiol Immunol Infect. 2024 Feb;57(1):138-147. doi: 10.1016/j.jmii.2023.10.014. Epub 2023 Nov 3.
7
Molecular characterization and virulence profile of Klebsiella pneumoniae and Klebsiella oxytoca isolated from ill cats and dogs in Portugal.从葡萄牙患病猫和狗中分离的肺炎克雷伯菌和产酸克雷伯菌的分子特征和毒力特征。
Vet Microbiol. 2024 May;292:110056. doi: 10.1016/j.vetmic.2024.110056. Epub 2024 Mar 16.
8
Comprehensive genomics reveals novel sequence types of multidrug resistant Klebsiella oxytoca with uncharacterized capsular polysaccharide K- and lipopolysaccharide O-antigen loci from the National Hospital of Uganda.综合基因组学揭示了来自乌干达国家医院的具有未表征荚膜多糖 K 和脂多糖 O-抗原基因座的多药耐药性产酸克雷伯菌的新型序列类型。
Infect Genet Evol. 2024 Sep;123:105640. doi: 10.1016/j.meegid.2024.105640. Epub 2024 Jul 11.
9
E. coli, K. pneumoniae and K. oxytoca community-acquired infections susceptibility to cephalosporins and other antimicrobials in Lebanon.黎巴嫩大肠杆菌、肺炎克雷伯菌和产酸克雷伯菌社区获得性感染对头孢菌素及其他抗菌药物的敏感性
J Med Liban. 2014 Apr-Jun;62(2):107-12. doi: 10.12816/0004106.
10
Genotypes of Klebsiella oxytoca isolates from patients with nosocomial pneumonia are distinct from those of isolates from patients with antibiotic-associated hemorrhagic colitis.医院获得性肺炎患者分离出的产酸克雷伯菌菌株的基因型与抗生素相关性出血性结肠炎患者分离出的菌株基因型不同。
J Clin Microbiol. 2014 May;52(5):1607-16. doi: 10.1128/JCM.03373-13. Epub 2014 Mar 5.

引用本文的文献

1
Nodules-associated Klebsiella oxytoca complex: genomic insights into plant growth promotion and health risk assessment.与结节相关的产酸克雷伯菌复合体：植物生长促进和健康风险评估的基因组学见解
BMC Microbiol. 2025 May 15;25(1):294. doi: 10.1186/s12866-025-04002-7.
2
Unraveling the genomic epidemiology and plasmid-mediated carbapenem resistance of .解析……的基因组流行病学及质粒介导的碳青霉烯类耐药性
Front Microbiol. 2025 Mar 17;16:1561624. doi: 10.3389/fmicb.2025.1561624. eCollection 2025.
3
Hospital toilets and drainage systems as a reservoir for a long-term polyclonal outbreak of clinical infections with multidrug-resistant species complex.医院卫生间和排水系统作为多重耐药菌复合种临床感染长期多克隆暴发的储存库。
Infect Prev Pract. 2024 Dec 21;7(1):100430. doi: 10.1016/j.infpip.2024.100430. eCollection 2025 Mar.
4
Global distribution of producing extended-spectrum β-lactamases in neonates.新生儿中产超广谱β-内酰胺酶的全球分布情况。
Precis Clin Med. 2024 Nov 6;7(4):pbae031. doi: 10.1093/pcmedi/pbae031. eCollection 2024 Dec.
5
Characterization of a Highly Virulent Strain Isolated from a Preterm Infant with Sepsis.从一名患有败血症的早产儿中分离出的高毒力菌株的特征分析。
Infect Drug Resist. 2024 Nov 9;17:4973-4983. doi: 10.2147/IDR.S481750. eCollection 2024.
6
Metagenome mining divulges virulent and multidrug resistant ST242 and ST∗1b23 coinfecting an 8-month-old meningitis infant under ICU in Kampala, Uganda, East Africa.宏基因组挖掘揭示了在东非乌干达坎帕拉一家重症监护病房中，一株毒力强且耐多药的ST242和一株ST∗1b23共同感染一名8个月大的脑膜炎婴儿。
Heliyon. 2024 Oct 20;10(20):e39455. doi: 10.1016/j.heliyon.2024.e39455. eCollection 2024 Oct 30.
7
Epidemiology and antimicrobial resistance of toxin-producing clinical isolates from children admitted to the oncology chemotherapy center in Mofid Children's Hospital in Tehran, Iran: A cross-sectional study.伊朗德黑兰莫菲德儿童医院肿瘤化疗中心收治儿童产毒素临床分离株的流行病学及抗菌药物耐药性：一项横断面研究
Health Sci Rep. 2024 Jul 31;7(8):e2275. doi: 10.1002/hsr2.2275. eCollection 2024 Aug.
8
Comprehensive genomics reveals novel sequence types of multidrug resistant Klebsiella oxytoca with uncharacterized capsular polysaccharide K- and lipopolysaccharide O-antigen loci from the National Hospital of Uganda.综合基因组学揭示了来自乌干达国家医院的具有未表征荚膜多糖 K 和脂多糖 O-抗原基因座的多药耐药性产酸克雷伯菌的新型序列类型。
Infect Genet Evol. 2024 Sep;123:105640. doi: 10.1016/j.meegid.2024.105640. Epub 2024 Jul 11.
9
Core genome multilocus sequence typing (cgMLST) applicable to the monophyletic species complex.核心基因组多位点序列分型 (cgMLST) 适用于单系种复合体。
J Clin Microbiol. 2024 Jun 12;62(6):e0172523. doi: 10.1128/jcm.01725-23. Epub 2024 May 23.
10
Pyogenic liver abscess associated with : Mimicking invasive liver abscess syndrome.化脓性肝脓肿合并：酷似侵袭性肝脓肿综合征。
Heliyon. 2023 Oct 31;9(11):e21537. doi: 10.1016/j.heliyon.2023.e21537. eCollection 2023 Nov.

本文引用的文献

1
Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.产酸克雷伯菌复合体：分类学、抗菌耐药性和毒力的最新研究进展。
Clin Microbiol Rev. 2022 Jan 19;35(1):e0000621. doi: 10.1128/CMR.00006-21. Epub 2021 Dec 1.
2
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study.基于全基因组序列信息的 MALDI-TOF MS 诊断揭示了产酸克雷伯菌在侵袭性感染中的重要性：一项回顾性临床研究。
Genome Med. 2021 Sep 13;13(1):150. doi: 10.1186/s13073-021-00960-5.
3
KEGG mapping tools for uncovering hidden features in biological data.KEGG 映射工具可用于揭示生物数据中的隐藏特征。
Protein Sci. 2022 Jan;31(1):47-53. doi: 10.1002/pro.4172. Epub 2021 Aug 26.
4
KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis.KOBAS-i：用于基因富集分析的生物学功能智能优先级排序和探索性可视化。
Nucleic Acids Res. 2021 Jul 2;49(W1):W317-W325. doi: 10.1093/nar/gkab447.
5
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation.交互式生命树 (iTOL) v5：一个用于显示和注释系统发育树的在线工具。
Nucleic Acids Res. 2021 Jul 2;49(W1):W293-W296. doi: 10.1093/nar/gkab301.
6
The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive in a Multi-Country Collection.多国收集的侵袭性菌株中脂多糖（O）和荚膜多糖（K）抗原的多样性
Front Microbiol. 2020 Jun 12;11:1249. doi: 10.3389/fmicb.2020.01249. eCollection 2020.
7
Prevalence and Characteristics of Extended-Spectrum-β-Lactamase-Producing and Carbapenemase-Producing from Freshwater Fish and Pork in Wet Markets of Hong Kong.香港湿街市售淡水鱼和猪肉中产超广谱β-内酰胺酶和碳青霉烯酶的耐药菌的流行情况及耐药特征。
mSphere. 2020 Apr 15;5(2):e00107-20. doi: 10.1128/mSphere.00107-20.
8
Population genomics of Klebsiella pneumoniae.肺炎克雷伯氏菌的群体基因组学。
Nat Rev Microbiol. 2020 Jun;18(6):344-359. doi: 10.1038/s41579-019-0315-1. Epub 2020 Feb 13.
9
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era.IQ-TREE 2：基因组时代系统发育推断的新模型和有效方法。
Mol Biol Evol. 2020 May 1;37(5):1530-1534. doi: 10.1093/molbev/msaa015.
10
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.南非比勒陀利亚耐多药临床肺炎克雷伯菌的病原体基因组学和进化流行病学研究。
Sci Rep. 2020 Jan 27;10(1):1232. doi: 10.1038/s41598-020-58012-8.