Zou Daoyang, Xin Xi, Xu Yunxian, Xu Huangzhen, Xu Tianwen
The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Ganzhou People's Hospital, Ganzhou, China.
Sci Rep. 2025 Jan 26;15(1):3297. doi: 10.1038/s41598-025-88067-4.
Colon cancer poses a significant threat to global health, and studies have shown a correlation between physical activity (PA) and the incidence of colon cancer. However, existing research has not quantitatively analyzed PA to evaluate its impact on the risk of colon cancer comprehensively. Data related to the study were obtained from the NHANES database for participants aged 20 and above between 2007 and 2018. Calculate the daily total metabolic equivalent (MET) based on the duration of different physical activities for each participant, use multivariate logistic regression analysis to evaluate the association between PA and colon cancer risk, perform subgroup analysis to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) between different subgroups, and use RCS regression analysis to evaluate the non-linear relationship between MET and colon cancer risk. After adjusting for potential confounding factors, multivariate logistic regression analysis showed that compared with the overall data of the participants in this study, the OR of the low PA group (PA ≤ 120MET/day) was 1.224 (95% CI 1.031-1.453, P = 0.023), the OR of the mild PA group (120 < PA ≤ 600MET/day) was 1.026 (95%CI 0.707-1.488, P = 0.894), the OR of the moderate intensity PA group (600 < PA ≤ 1200MET/day) was 0.798 (95% CI 0.506-1.258, P = 0.334), and the OR of the high-intensity PA group (PA > 1200MET/day) was 0.470 (95% CI 0.249-0.885, P = 0.022), these results are consistent in subgroup analysis. The RCS regression analysis results showed a significant nonlinear relationship between MET and the risk of colon cancer(p < 0.001), with an inflection point observed at 1879 MET/day on the correlation curve. Low physical activity increases the risk of colon cancer, while moderate to high-intensity physical activity can reduce the risk of colon cancer. The results of this study emphasize the importance of maintaining appropriate physical activity as a healthy way to prevent colon cancer.
结肠癌对全球健康构成重大威胁，研究表明身体活动（PA）与结肠癌发病率之间存在关联。然而，现有研究尚未对PA进行定量分析，以全面评估其对结肠癌风险的影响。本研究相关数据来自2007年至2018年年龄在20岁及以上参与者的美国国家健康与营养检查调查（NHANES）数据库。根据每位参与者不同身体活动的持续时间计算每日总代谢当量（MET），使用多因素逻辑回归分析评估PA与结肠癌风险之间的关联，进行亚组分析以计算不同亚组之间的调整比值比（OR）和95%置信区间（CI），并使用限制立方样条（RCS）回归分析评估MET与结肠癌风险之间的非线性关系。在调整潜在混杂因素后，多因素逻辑回归分析显示，与本研究参与者的总体数据相比，低PA组（PA≤120MET/天）的OR为1.224（95%CI 1.031 - 1.453，P = 0.023），轻度PA组（120＜PA≤600MET/天）的OR为1.026（95%CI 0.707 - 1.488，P = 0.894），中等强度PA组（600＜PA≤1200MET/天）的OR为0.798（95%CI 0.506 - 1.258，P = 0.334），高强度PA组（PA＞1200MET/天）的OR为0.470（95%CI 0.249 - 0.885，P = 0.022），这些结果在亚组分析中一致。RCS回归分析结果显示MET与结肠癌风险之间存在显著的非线性关系（P＜0.001），在相关曲线上观察到拐点为1879 MET/天。低身体活动会增加结肠癌风险，而中等至高强度身体活动可降低结肠癌风险。本研究结果强调了保持适当身体活动作为预防结肠癌的健康方式的重要性。
