植物来源的细胞外囊泡作为治疗性纳米载体。
Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers.
机构信息
Laboratory for Biomaterials and Computational Mechanics, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, Greece.
Graduate Program in Biomedical Engineering, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, Greece.
出版信息
Int J Mol Sci. 2021 Dec 24;23(1):191. doi: 10.3390/ijms23010191.
Mammalian exosomes have emerged as a promising class of functional materials, inspiring novel applications as therapeutic vehicles and nutraceutical compounds. Despite this, their immunogenicity has been an issue of controversy within the scientific community. Although, exosome-like vesicles, innately formed in plants and inherent to eukaryotic cell-derived vesicles, could soothe most of the concerns, they are notably underutilized as therapeutic modalities. This review highlights all efforts published so far, on the use of plant-derived extracellular vesicles (EVs) as therapeutic delivery systems. A summary of the physicochemical characteristics of plant-derived EVs is provided along with their main biological composition and in vitro/in vivo evidence of their therapeutic efficacy provided where available. Despite only a hand full of clinical trials being underway, concerning these vesicles, they arguably possess significant potential as nanodelivery systems of natural origin.
哺乳动物外泌体作为一类有前途的功能材料已经出现，激发了作为治疗载体和营养化合物的新应用。尽管如此，它们的免疫原性一直是科学界争议的问题。然而，植物天然形成的类外泌体小泡和真核细胞衍生的小泡固有存在，可以缓解大多数关注问题，但它们作为治疗方式的应用明显不足。这篇综述强调了迄今为止发表的关于利用植物来源的细胞外囊泡 (EVs) 作为治疗性递药系统的所有努力。提供了植物来源的 EVs 的理化特性的摘要，以及它们的主要生物学组成，并在有条件的情况下提供了它们的治疗功效的体外/体内证据。尽管只有少数临床试验正在进行中，但这些囊泡可以作为天然来源的纳米递药系统具有重要的潜力。
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