HTLV-III抗体呈阳性的重型β地中海贫血患者的免疫变化
Immunological changes in beta-thalassemia major patients positive for HTLV-III antibodies.
作者信息
Romeo M A, Russo Mancuso G, Mauro L, Sciotto A, Romeo M A, Di Gregorio F, Giammanco G, Schiliro G
机构信息
Istituti di Clinica Pediatrica I, Università di Catania, Italy.
出版信息
Eur J Epidemiol. 1987 Dec;3(4):451-3. doi: 10.1007/BF00145663.
Antibodies to HTLV-III were found in 6 of 206 Sicilian patients with thalassemia major, aged 1 to 30 years. None of the patients showed clinical signs related to immuno-deficiency syndromes. Immunological investigations carried out in all positive patients showed alterations similar to those found in thalassemic patients without antibodies to HTLV-III. These immunological changes could not depend on the HTLV-III infection, but could be related to the thalassemic condition.
在206名年龄在1至30岁之间的西西里重型地中海贫血患者中，有6人检测出抗HTLV - III抗体。所有患者均未表现出与免疫缺陷综合征相关的临床症状。对所有阳性患者进行的免疫学调查显示，其改变与未感染HTLV - III抗体的地中海贫血患者相似。这些免疫学变化并非由HTLV - III感染引起，而可能与地中海贫血病情有关。
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