Shannon K, Ball E, Wasserman R L, Murphy F K, Luby J, Buchanan G R
J Pediatr. 1983 Dec;103(6):859-63. doi: 10.1016/s0022-3476(83)80701-x.
An infant who received multiple blood transfusions in the neonatal intensive care unit developed a transfusion-associated CMV infection at age 11 weeks and thereafter was noted to have hepatosplenomegaly, mitogen hyporesponsiveness, persistent viruria, an abnormal distribution of T-lymphocyte subpopulations, and poor growth. He has had recurrent opportunistic infections, including Pneumocystis carinii pneumonia. Six donors of blood products received by this infant were investigated; one was found to have chronic lymphadenopathy, weight loss, intermittent diarrhea, lymphopenia, and a profound depression of lymphocytes with a helper/inducer surface phenotype (T4 positive). Family members have an abnormal distribution of T cell subpopulations similar to those reported in asymptomatic homosexuals. The course of disease in our patient suggests that acquired immune deficiency syndrome may be transmitted to young infants via blood products.
一名在新生儿重症监护病房接受多次输血的婴儿在11周龄时发生了输血相关的巨细胞病毒感染，此后被发现有肝脾肿大、丝裂原低反应性、持续性病毒尿、T淋巴细胞亚群分布异常以及生长发育不良。他曾反复发生机会性感染，包括卡氏肺孢子虫肺炎。对该婴儿接受的6名血液制品捐献者进行了调查；其中1人有慢性淋巴结病、体重减轻、间歇性腹泻、淋巴细胞减少以及具有辅助/诱导表面表型（T4阳性）的淋巴细胞显著减少。家庭成员的T细胞亚群分布异常，与无症状同性恋者中报道的情况相似。我们患者的病程表明，获得性免疫缺陷综合征可能通过血液制品传播给幼儿。
