Church J A, Isaacs H
J Pediatr. 1984 Nov;105(5):731-7. doi: 10.1016/s0022-3476(84)80292-9.
Two preterm infant boys not known to be at risk developed clinical, laboratory, and pathologic features of acquired immune deficiency syndrome (AIDS) after receiving multiple blood transfusions in the neonatal period. Their clinical courses were characterized by failure to thrive, recurrent otitis media, hepatomegaly, and fatal interstitial pneumonia. Laboratory evaluation revealed progressive lymphopenia, reversed T helper/suppressor ratios, increased percentages of B-lymphocytes, decreased lymphoproliferative responses to mitogens, hyperimmunoglobulinemia, and high levels of circulating immune complexes. At postmortem examination thymic involution, lymphocyte depletion in spleen and lymph nodes, and micronodular mineralization in the central nervous system were seen. The findings were not specific for other known congenital immune deficiencies and were most indicative of AIDS. The lack of other risk factors suggests transmission of AIDS via blood transfusions in the neonatal period.
两名无已知风险因素的早产男婴在新生儿期接受多次输血后，出现了获得性免疫缺陷综合征（艾滋病）的临床、实验室和病理特征。他们的临床病程表现为生长发育迟缓、复发性中耳炎、肝肿大以及致命性间质性肺炎。实验室检查显示进行性淋巴细胞减少、T辅助/抑制细胞比例倒置、B淋巴细胞百分比增加、对有丝分裂原的淋巴细胞增殖反应降低、高免疫球蛋白血症以及循环免疫复合物水平升高。尸检发现胸腺萎缩、脾脏和淋巴结淋巴细胞耗竭以及中枢神经系统微小结节矿化。这些发现并非其他已知先天性免疫缺陷所特有，最符合艾滋病的表现。缺乏其他风险因素提示艾滋病是通过新生儿期输血传播的。
