Sack Carolin, Ferrari Nina, Friesen David, Haas Fabiola, Klaudius Marlen, Schmidt Lisa, Torbahn Gabriel, Wulff Hagen, Joisten Christine
Department for Physical Activity in Public Health, Institute of Movement and Neurosciences, Am Sportpark Müngersdorf 6, German Sport University Cologne, 50933 Cologne, Germany.
Cologne Center for Prevention in Childhood and Youth/Heart Center Cologne, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
J Clin Med. 2022 Jan 5;11(1):277. doi: 10.3390/jcm11010277.
Sarcopenic obesity is increasingly found in youth, but its health consequences remain unclear. Therefore, we studied the prevalence of sarcopenia and its association with cardiometabolic risk factors as well as muscular and cardiorespiratory fitness using data from the German Children's Health InterventionaL Trial (CHILT III) programme. In addition to anthropometric data and blood pressure, muscle and fat mass were determined with bioelectrical impedance analysis. Sarcopenia was classified via muscle-to-fat ratio. A fasting blood sample was taken, muscular fitness was determined using the standing long jump, and cardiorespiratory fitness was determined using bicycle ergometry. Of the 119 obese participants included in the analysis (47.1% female, mean age 12.2 years), 83 (69.7%) had sarcopenia. Affected individuals had higher gamma-glutamyl transferase, higher glutamate pyruvate transaminase, higher high-sensitivity C-reactive protein, higher diastolic blood pressure, and lower muscular and cardiorespiratory fitness (each < 0.05) compared to participants who were 'only' obese. No differences were found in other parameters. In our study, sarcopenic obesity was associated with various disorders in children and adolescents. However, the clinical value must be tested with larger samples and reference populations to develop a unique definition and appropriate methods in terms of identification but also related preventive or therapeutic approaches.
肌肉减少性肥胖在青少年中越来越常见，但其对健康的影响尚不清楚。因此，我们利用德国儿童健康干预试验（CHILT III）项目的数据，研究了肌肉减少症的患病率及其与心血管代谢危险因素以及肌肉和心肺适能的关系。除了人体测量数据和血压外，还通过生物电阻抗分析测定肌肉和脂肪量。肌肉减少症通过肌肉与脂肪比例进行分类。采集空腹血样，通过立定跳远测定肌肉适能，通过自行车测力计测定心肺适能。在纳入分析的119名肥胖参与者中（47.1%为女性，平均年龄12.2岁），83人（69.7%）患有肌肉减少症。与“仅”肥胖的参与者相比，受影响的个体具有更高的γ-谷氨酰转移酶、更高的谷丙转氨酶、更高的高敏C反应蛋白、更高的舒张压，以及更低的肌肉和心肺适能（均P<0.05）。在其他参数方面未发现差异。在我们的研究中，肌肉减少性肥胖与儿童和青少年的各种疾病有关。然而，必须通过更大的样本和参考人群来检验其临床价值，以便在识别方面制定独特的定义和适当的方法，以及相关的预防或治疗方法。
