当干细胞遇上 COVID-19：最新进展、挑战与未来展望。
When stem cells meet COVID-19: recent advances, challenges and future perspectives.
机构信息
Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, 410008, China.
出版信息
Stem Cell Res Ther. 2022 Jan 10;13(1):9. doi: 10.1186/s13287-021-02683-1.
Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory coronavirus 2 is currently spreading throughout the world with a high rate of infection and mortality and poses a huge threat to global public health. COVID-19 primarily manifests as hypoxic respiratory failure and acute respiratory distress syndrome, which can lead to multiple organ failure. Despite advances in the supportive care approaches, there is still a lack of clinically effective therapies, and there is an urgent need to develop novel strategies to fight this disease. Currently, stem cell therapy and stem cell-derived organoid models have received extensive attention as a new treatment and research method for COVID-19. Here, we discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.
新型严重急性呼吸综合征冠状病毒 2 引起的 2019 年冠状病毒病 (COVID-19) 目前在全球范围内广泛传播，感染率和死亡率高，对全球公共卫生构成巨大威胁。COVID-19 主要表现为低氧性呼吸衰竭和急性呼吸窘迫综合征，可导致多器官衰竭。尽管支持治疗方法有所进展，但仍缺乏临床有效的治疗方法，迫切需要开发新的策略来对抗这种疾病。目前，干细胞治疗和干细胞衍生的类器官模型作为 COVID-19 的一种新的治疗和研究方法受到广泛关注。在这里，我们讨论了干细胞在对抗 COVID-19 中的作用，并对 COVID-19 的干细胞治疗和类器官模型的研究进行了系统的回顾和展望，为全球 COVID-19 大流行的有效控制提供了参考。
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