Kjartansson J, Dalsgaard C J
Department of Plastic and Reconstructive Surgery, Karolinska Hospital, Stockholm, Sweden.
Eur J Pharmacol. 1987 Oct 27;142(3):355-8. doi: 10.1016/0014-2999(87)90073-2.
Calcitonin gene-related peptide (CGRP) was shown to increase the survival area of ischaemic tissue from 45% in control animals to about 90% in treated animals. This effect was demonstrated in a musculocutaneous flap model in the rat. The concentrations used were 2 X 10(5) times lower than those known to cause an increase in skin blood flow under normal conditions. Treatment with one single dose up to 36 h postoperatively was found to increase the flap survival area. It is suggested that the mechanism/s by which CGRP increases survival of ischaemic tissue may be different from vasodilation or that the sensitivity is altered during ischaemic conditions and that CGRP may be a powerful tool to reduce ischemia in various clinical conditions.
降钙素基因相关肽（CGRP）可使缺血组织的存活面积从对照动物的45%增加至治疗动物的约90%。该效应在大鼠肌皮瓣模型中得到证实。所用浓度比已知在正常条件下引起皮肤血流增加的浓度低2×10⁵倍。发现术后单次给药直至术后36小时进行治疗可增加皮瓣存活面积。提示CGRP增加缺血组织存活的机制可能不同于血管舒张，或者在缺血状态下敏感性发生改变，并且CGRP可能是在各种临床情况下减少缺血的有力工具。
