Mapp P I, Walsh D A, Garrett N E, Kidd B L, Cruwys S C, Polak J M, Blake D R
Inflammation Group, Royal London Hospital Medical College, London, United Kingdom.
Ann Rheum Dis. 1994 Apr;53(4):240-6. doi: 10.1136/ard.53.4.240.
Both sensory and sympathetic nerve fibres are depleted in the synovium in rheumatoid arthritis (RA). The hypothesis that the induction of an inflammatory response in the synovium is capable of causing depletion of nerve fibres was tested.
To investigate this phenomenon experimental arthritis in the rat was induced by three different methods and the synovium was examined for evidence of nerve depletion by immunocytochemistry.
In a synovitis induced by latex spheres, a mainly macrophage foreign body type reaction, no nerve depletion was seen. In contrast both in an antigen-induced and a hydrogen peroxide-induced model of arthritis nerve fibre depletion was observed. This appeared to affect sensory and sympathetic nerve fibres equally. Nerve fibre depletion was only seen in areas of inflammatory cell infiltration indicating that a mixed lymphocyte and macrophage population of cells may be necessary for this effect.
An inflammatory response, containing lymphocytes and macrophages, in the synovium is capable of the depletion of the finely myelinated and unmyelinated neuropeptide-containing nerves.
类风湿关节炎（RA）患者滑膜中的感觉神经纤维和交感神经纤维均减少。本研究对滑膜中炎症反应的诱导是否能够导致神经纤维减少这一假说进行了验证。
为研究该现象，采用三种不同方法诱导大鼠实验性关节炎，并通过免疫细胞化学检查滑膜，以寻找神经纤维减少的证据。
在由乳胶球诱导的滑膜炎（一种主要为巨噬细胞异物型反应）中，未观察到神经纤维减少。相比之下，在抗原诱导和过氧化氢诱导的关节炎模型中均观察到神经纤维减少。这似乎对感觉神经纤维和交感神经纤维的影响相同。神经纤维减少仅见于炎症细胞浸润区域，表明混合的淋巴细胞和巨噬细胞群体可能是产生这种效应所必需的。
滑膜中包含淋巴细胞和巨噬细胞的炎症反应能够导致含神经肽的细有髓和无髓神经纤维减少。
