Lackey A, Pruett S B
Department of Biological Sciences, Mississippi State University, MS 39762.
Immunol Invest. 1987 Jun;16(4):333-43. doi: 10.3109/08820138709087088.
The results presented here demonstrate that mouse serum lipoproteins inhibit Interleukin 2 (IL2)-mediated proliferation of CTLL-2 cells. Lipoproteins account for a variable portion (29-83%) of the total inhibitory activity of whole serum and are not specific inhibitors of IL2-mediated cell proliferation, as evidenced by their inhibitory activity for non-IL2-dependent MPC 11 cells. Lipoproteins did not accelerate the death of CTLL-2 cells deprived of IL2, indicating that their inhibition of proliferation is not due to toxic effects. Finally, the inhibitory activity of serum and isolated lipoproteins was increased when the donor mice were maintained on a diet high in polyunsaturated fats for 16 days prior to bleeding. These findings provide a basis for future investigations of the relationship between dietary fats, lipoprotein quantity and composition, and alteration of immune responses.
此处呈现的结果表明，小鼠血清脂蛋白可抑制白细胞介素2（IL2）介导的CTLL-2细胞增殖。脂蛋白在全血清总抑制活性中所占比例可变（29%-83%），并非IL2介导的细胞增殖的特异性抑制剂，这一点可由其对非IL2依赖性MPC 11细胞的抑制活性得到证明。脂蛋白不会加速缺乏IL2的CTLL-2细胞的死亡，这表明其对增殖的抑制并非由毒性作用所致。最后，当供体小鼠在采血前16天食用富含多不饱和脂肪的饮食时，血清和分离出的脂蛋白的抑制活性会增强。这些发现为未来研究膳食脂肪、脂蛋白数量和组成与免疫反应改变之间的关系提供了基础。
