Department of Food Science, University of Massachusetts, Amherst, Massachusetts United States.
ACS Appl Bio Mater. 2021 Jan 18;4(1):295-310. doi: 10.1021/acsabm.0c01349. Epub 2020 Dec 21.
Mycotoxins are toxic metabolites produced by fungi that contaminate many important crops worldwide. Humans are commonly exposed to mycotoxins through the consumption of contaminated food products. Mycotoxin contamination is unpredictable and unavoidable; it occurs at any point in the food production system under favorable conditions, and they cannot be destroyed by common heat treatments, because of their high thermal stability. Early and fast detection plays an essential role in this unique challenge to monitor the presence of these compounds in the food chain. Surface-enhanced Raman spectroscopy (SERS) is an advanced spectroscopic technique that integrates Raman spectroscopic molecular fingerprinting and enhanced sensitivity based on nanotechnology to meet the requirement of sensitivity and selectivity, but that can also be performed in a cost-effective and straightforward manner. This Review focuses on the SERS methodologies applied to date for qualitative and quantitative analysis of mycotoxins based on a variety of SERS substrates, as well as our perspectives on current limitations and future trends for applying this technique to mycotoxin analyses.
真菌产生的霉菌毒素是有毒的代谢物，会污染全世界许多重要的农作物。人类通常通过食用受污染的食品接触到霉菌毒素。霉菌毒素污染是不可预测和不可避免的；在有利条件下，它会在食品生产系统的任何阶段发生，而且由于其热稳定性高，普通的热处理方法无法将其破坏。早期和快速检测在监测这些化合物在食物链中存在的这一独特挑战中起着至关重要的作用。表面增强拉曼光谱（SERS）是一种先进的光谱技术，它将拉曼光谱分子指纹图谱和基于纳米技术的增强灵敏度相结合，以满足灵敏度和选择性的要求，但也可以以具有成本效益且简单的方式进行。这篇综述重点介绍了迄今为止应用于基于各种 SERS 基底的霉菌毒素定性和定量分析的 SERS 方法，以及我们对将该技术应用于霉菌毒素分析的当前局限性和未来趋势的看法。
