Kitani A, Hara M, Hirose T, Norioka K, Hirose W, Harigai M, Suzuki K, Kawagoe M, Shinmei M, Nakamura H
First Department of Medicine, National Defense Medical College, Saitama, Japan.
J Rheumatol. 1987 Oct;14(5):873-9.
B cell differentiation activity assayed on B cells preactivated by Staphylococcus aureus Cowan I was found in synovial fluids (SF) of patients with rheumatoid arthritis (RA) (n = 14), while little, if any, activity was found in SF of patients without RA (n = 13) including patients with osteoarthritis and traumatic arthritis. There was a positive correlation between the RA hemagglutination assay titer and B cell differentiation activity (r = 0.7438). This molecule with molecular weight ranges 15-20 kDa as well as supernatant from phytohemaglutinin stimulated normal T cells could promote not only polyvalent immunoglobulin synthesis but also rheumatoid factor synthesis by lymphocytes from patients with RA in vitro, and was considered to be distinct from interleukin-1, interleukin-2, interferon r, or proteolytic lysosomal enzymes which have been shown to modulate B cell activation.
在类风湿性关节炎（RA）患者（n = 14）的滑液（SF）中发现了对经金黄色葡萄球菌考恩I预激活的B细胞进行检测的B细胞分化活性，而在包括骨关节炎和创伤性关节炎患者在内的无RA患者（n = 13）的SF中几乎未发现活性（如果有活性的话也极少）。RA血凝试验滴度与B细胞分化活性之间存在正相关（r = 0.7438）。这种分子量范围为15 - 20 kDa的分子以及来自植物血凝素刺激的正常T细胞的上清液不仅可以促进多价免疫球蛋白的合成，还能在体外促进RA患者淋巴细胞合成类风湿因子，并且被认为与已被证明可调节B细胞活化的白细胞介素-1、白细胞介素-2、干扰素γ或蛋白水解溶酶体酶不同。
