用于灵敏且选择性检测肿瘤细胞的氙气超极化化学交换饱和转移/功能磁共振成像多模态成像系统
Xe Hyper-CEST/F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection.
作者信息
Zhang Huaibin, Chen Shizhen, Yuan Yaping, Li Yu, Jiang ZhongXing, Zhou Xin
机构信息
State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center forMagnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
出版信息
ACS Appl Bio Mater. 2019 Jan 22;2(1):27-32. doi: 10.1021/acsabm.8b00635. Epub 2018 Dec 26.
Heteronuclear MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Here we report a novel method for simultaneous acquisition of dual-nuclei hyper-CEST Xe and F tumor targeting MRI. Xe hyper-CEST MRI, F MRI and fluorescent imaging were integrated into PFOB nanoemulsion as a imaging system for sensitive and selective tumor cells detection. As the complement to H MRI, Xe and F signals can also provide efficient and precise anatomical localization of tumors.
异核磁共振成像在诊断、治疗规划或监测中对分子靶向药物进行特异性检测和定量分析方面具有广阔的潜力。在此，我们报告一种同时采集双核超极化化学交换饱和转移（hyper-CEST）氙和氟肿瘤靶向磁共振成像的新方法。氙超极化化学交换饱和转移磁共振成像、氟磁共振成像和荧光成像被整合到全氟溴辛烷纳米乳剂中，作为一种用于灵敏且选择性地检测肿瘤细胞的成像系统。作为氢磁共振成像的补充，氙和氟信号还可以为肿瘤提供高效且精确的解剖定位。
Zotero 插件