Department of Stomatology 2, The Fourth Clinical College of Xinxiang Medical University, Xinxiang, China.
Ann Palliat Med. 2021 Dec;10(12):12664-12677. doi: 10.21037/apm-21-3449.
With the continuous improvement of human living standards, more and more dental patients are requiring oral implant restoration treatment. However, there is still controversy regarding the influence of risk factors such as osteoporosis, radiotherapy, diabetes, and smoking on the failure of oral implants. This study aimed to explore the correlation between risk factors and failure of oral implant restoration treatment.
The databases of China National Knowledge Infrastructure (CNKI), Baidu Academic, Weipu, Wanfang, PubMed, EBSCO, Medline, Web of knowledge, Ovid, and the Cochrane Library were searched. The search strategies included: subject terms related to research results such as survival, osseointegration, failure, removal, replacement, and loss; related to risk factors: osteoporosis, head and neck cancer, diabetes, and smoking; and oral implantology as a keyword.
Thirty-two articles were included in meta-analysis, there was a high heterogeneity between radiotherapy and dental implant failure (I2=71.6%, P=0.000), and there was an obvious correlation between radiotherapy and dental implant failure [relative risk (RR) =2.09, 95% confidential interval (CI): 1.68-2.61]. There was heterogeneity between diabetes and oral implant failure in the included articles (I2=59.6%, P=0.084). There was no remarkable correlation between osteoporosis and dental implant failure (RR =1.19, 95% CI: 0.81-1.74). There was a high heterogeneity between smoking and dental implant failure in the included articles (I2=33.8%, P=0.092), showing obvious correlation (RR =1.80, 95% CI: 1.53-2.11).
The results of meta-analysis confirmed that radiotherapy and smoking were greatly associated with oral implant failure.
随着人类生活水平的不断提高，越来越多的牙科患者需要接受口腔种植修复治疗。然而，骨质疏松症、放疗、糖尿病和吸烟等危险因素对口腔种植体失败的影响仍存在争议。本研究旨在探讨危险因素与口腔种植修复治疗失败的相关性。
在中国知网（CNKI）、百度学术、维普、万方、PubMed、EBSCO、Medline、Web of knowledge、Ovid、Cochrane 图书馆等数据库中进行检索。检索策略包括：与研究结果相关的主题词，如生存、骨整合、失败、移除、替换和损失；与危险因素相关的主题词，如骨质疏松症、头颈部癌症、糖尿病和吸烟；以及口腔种植学作为关键词。
共有 32 篇文章纳入荟萃分析，放疗与牙种植体失败之间存在高度异质性（I2=71.6%，P=0.000），且放疗与牙种植体失败明显相关[相对风险（RR）=2.09，95%可信区间（CI）：1.68-2.61]。纳入的文章中糖尿病与口腔种植体失败之间存在异质性（I2=59.6%，P=0.084）。骨质疏松症与牙种植体失败无显著相关性（RR=1.19，95%CI：0.81-1.74）。纳入的文章中吸烟与牙种植体失败之间存在高度异质性（I2=33.8%，P=0.092），显示明显相关性（RR=1.80，95%CI：1.53-2.11）。
荟萃分析结果证实，放疗和吸烟与口腔种植体失败密切相关。
