Lu Wei, Li Jian-Ping, Jiang Zhen-Dong, Yang Lin, Liu Xue-Zheng
Department of Human Anatomy, School of Basic Medical Scinences, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Department of Human Anatomy, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong Province, China.
Department of Human Anatomy, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong Province, China.
Neural Regen Res. 2022 Aug;17(8):1827-1832. doi: 10.4103/1673-5374.332153.
Targeted muscle reinnervation (TMR) is a surgical procedure used to transfer residual peripheral nerves from amputated limbs to targeted muscles, which allows the target muscles to become sources of motor control information for function reconstruction. However, the effect of TMR on injured motor neurons is still unclear. In this study, we aimed to explore the effect of hind limb TMR surgery on injured motor neurons in the spinal cord of rats after tibial nerve transection. We found that the reduction in hind limb motor function and atrophy in mice caused by tibial nerve transection improved after TMR. TMR enhanced nerve regeneration by increasing the number of axons and myelin sheath thickness in the tibial nerve, increasing the number of anterior horn motor neurons, and increasing the number of choline acetyltransferase-positive cells and immunofluorescence intensity of synaptophysin in rat spinal cord. Our findings suggest that TMR may enable the reconnection of residual nerve fibers to target muscles, thus restoring hind limb motor function on the injured side.
靶向肌肉再支配（TMR）是一种外科手术，用于将截肢肢体的残余周围神经转移到目标肌肉，使目标肌肉成为功能重建的运动控制信息来源。然而，TMR对受损运动神经元的影响仍不清楚。在本研究中，我们旨在探讨后肢TMR手术对大鼠胫神经横断后脊髓中受损运动神经元的影响。我们发现，TMR术后，由胫神经横断引起的小鼠后肢运动功能减退和萎缩得到改善。TMR通过增加胫神经中的轴突数量和髓鞘厚度、增加前角运动神经元数量、增加大鼠脊髓中胆碱乙酰转移酶阳性细胞数量和突触素免疫荧光强度来促进神经再生。我们的研究结果表明，TMR可能使残余神经纤维与目标肌肉重新连接，从而恢复损伤侧的后肢运动功能。
