Ogawa Hiroshi, Damrongrungruang Teerasak, Hori Sayaka, Nouno Kaname, Minagawa Kumiko, Sato Misuzu, Miyazaki Hideo
Hiroshi Ogawa, Teerasak Damrongrungruang, Sayaka Hori, Kaname Nouno, Kumiko Minagawa, Misuzu Sato, Hideo Miyazaki, Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan.
World J Diabetes. 2014 Dec 15;5(6):924-31. doi: 10.4239/wjd.v5.i6.924.
The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal.
在过去二十年中，人们对脂肪因子与炎症性牙周疾病之间的关联进行了研究。本综述旨在探讨牙周治疗可能会改善糖尿病患者脂肪因子这一观察结果。总之，大量证据表明，糖尿病与牙周炎患病率、范围及严重程度的增加有关。人们已经阐明了多种机制来解释糖尿病对牙周组织的影响。然而，关于主要脂肪因子的作用，目前的认识仅表明它们与2型糖尿病牙周炎发病机制存在一些关联。相反，牙周疾病的治疗和口腔炎症的减轻可能对糖尿病病情产生积极影响，尽管这方面的证据仍有些模糊。
