银纳米颗粒绿色合成对致龋病原体的抗菌效果——一项研究
Antimicrobial Efficacy of Green Synthesis of Silver Nanoparticles against Cariogenic Pathogens - An Study.
作者信息
Chittrarasu M, Ahamed A Shafie, Ravi Vaiyapuri
机构信息
Department of Conservative, Dentistry and Endodontics, Vivekanandha Dental College for Women, Namakkal, The Tamil Nadu Dr. M.G.R. Medical University, Tamil Nadu, India.
Department of Conservative Dentistry and Endodontics, Rajah Muthiah Dental College, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
出版信息
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1188-S1192. doi: 10.4103/jpbs.jpbs_338_21. Epub 2021 Nov 10.
BACKGROUND
Nowadays, emergence of drug resistance might happen in the world. Hence, invention of new dental material had started by researchers for the same. The present study evaluated the antimicrobial property of green synthesized nanosilver particles against dental cariogenic microorganisms such as and .
MATERIALS AND METHODS
An study had been designed to meet the objectives. Galla Chinensis ellagic acid powder synthesized nanosilver particles (GCAgNPs) synthesized nanosilver particles were used in this study. The cariogenic bacteria (ATCC 25175) and (ATCC 4356) were used in this study. The antimicrobial activity was detected at different concentrations (1000 μg/ml, 500 μg/ml, 250 μg/ml, 125 μg/ml, and 62.5 μg/ml) by means of qualitative and quantitative methods.
RESULTS
The results show a statistically significant difference between all the concentration (1000 μg/ml, 500 μg/ml, 250 μg/ml, 125 μg/ml, 62.5 μg/ml) in Galla Chinensis synthesized silver nanoparticles (GCAgNPs) in and . Intergroup comparison of GCAgNPs shows a statistically significant difference among all the concentrations against and .
CONCLUSION
GCAgNPs show antimicrobial and antibiofilm activity against and microorganisms.
背景
如今，耐药性在全球范围内可能出现。因此，研究人员已开始研发新型牙科材料。本研究评估了绿色合成纳米银颗粒对变形链球菌和远缘链球菌等致龋微生物的抗菌性能。
材料与方法
设计了一项研究以实现这些目标。本研究使用了五倍子鞣花酸粉末合成的纳米银颗粒（GCAgNPs）。本研究中使用了致龋细菌变形链球菌（ATCC 25175）和远缘链球菌（ATCC 4356）。通过定性和定量方法检测了不同浓度（1000μg/ml、500μg/ml、250μg/ml、125μg/ml和62.5μg/ml）下的抗菌活性。
结果
结果表明，五倍子合成的银纳米颗粒（GCAgNPs）在1000μg/ml、500μg/ml、250μg/ml、125μg/ml、62.5μg/ml所有浓度下，在变形链球菌和远缘链球菌中的差异具有统计学意义。GCAgNPs的组间比较显示，在所有浓度下对变形链球菌和远缘链球菌的差异具有统计学意义。
结论
GCAgNPs对变形链球菌和远缘链球菌微生物显示出抗菌和抗生物膜活性。
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