Noronha Victor T, Paula Amauri J, Durán Gabriela, Galembeck Andre, Cogo-Müller Karina, Franz-Montan Michelle, Durán Nelson
Solid-Biological Interface Group (SolBIN), Department of Physics, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Solid-Biological Interface Group (SolBIN), Department of Physics, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Dent Mater. 2017 Oct;33(10):1110-1126. doi: 10.1016/j.dental.2017.07.002. Epub 2017 Aug 2.
Silver nanoparticles (AgNPs) have been extensively studied for their antimicrobial properties, which provide an extensive applicability in dentistry. Because of this increasing interest in AgNPs, the objective of this paper was to review their use in nanocomposites; implant coatings; pre-formulation with antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria; and other applications such as treatment of oral cancer and local anesthesia. Recent achievements in the study of the mechanism of action and the most important toxicological aspects are also presented.
Systematic searches were carried out in Web of Science (ISI), Google, PubMed, SciFinder and EspaceNet databases with the keywords "silver nano* or AgNP*" and "dentist* or dental* or odontol*".
A total of 155 peer-reviewed articles were reviewed. Most of them were published in the period of 2012-2017, demonstrating that this topic currently represents an important trend in dentistry research. In vitro studies reveal the excellent antimicrobial activity of AgNPs when associated with dental materials such as nanocomposites, acrylic resins, resin co-monomers, adhesives, intracanal medication, and implant coatings. Moreover, AgNPs were demonstrated to be interesting tools in the treatment of oral cancers due to their antitumor properties.
The literature indicates that AgNPs are a promising system with important features such as antimicrobial, anti-inflammatory and antitumor activity, and a potential carrier in sustained drug delivery. However, there are some aspects of the mechanisms of action of AgNPs, and some important toxicological aspects arising from the use of this system that must be completely elucidated.
银纳米颗粒（AgNPs）因其抗菌特性已得到广泛研究，在牙科领域具有广泛的应用前景。鉴于对AgNPs的兴趣日益增加，本文旨在综述其在纳米复合材料、植入物涂层、对致龋病原体、牙周生物膜、真菌病原体和牙髓细菌具有抗菌活性的预制剂以及其他应用（如口腔癌治疗和局部麻醉）中的应用。还介绍了作用机制研究的最新成果以及最重要的毒理学方面。
在科学网（ISI）、谷歌、PubMed、SciFinder和EspaceNet数据库中进行系统检索，关键词为“银纳米或AgNP”和“牙医或牙科或牙科学*”。
共综述了155篇同行评议文章。其中大部分发表于2012年至2017年期间，表明该主题目前是牙科研究的一个重要趋势。体外研究表明，当AgNPs与纳米复合材料、丙烯酸树脂、树脂共聚单体、粘合剂、根管内用药和植入物涂层等牙科材料结合时，具有优异的抗菌活性。此外，由于其抗肿瘤特性，AgNPs被证明是治疗口腔癌的有趣工具。
文献表明，AgNPs是一个有前途的体系，具有抗菌、抗炎和抗肿瘤活性等重要特性，是持续药物递送的潜在载体。然而，AgNPs作用机制的某些方面以及使用该体系产生的一些重要毒理学方面必须得到彻底阐明。
