Ye Zhiguo, Li Guixin, Lei Jing, Liu Mei, Jin Yan, Li Baoxin
School of Chemistry & Chemical Engineering, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, Shaanxi Normal University, Xi'an 710119, China.
School of Chemistry & Chemical Engineering, Xinjiang Normal University, Urumqi 830054, China.
ACS Appl Bio Mater. 2020 Oct 19;3(10):7095-7102. doi: 10.1021/acsabm.0c00923. Epub 2020 Sep 18.
Discovering efficient antibacterial materials is crucial in the area of increasing drug resistance. Herein, we synthesized carbon dots (C-dots) with superior antibacterial activity through a simple one-step hydrothermal method. In this method, -phenylenediamine serves as not only the carbon source but also the origin for the functional group anchored on the obtained C-dots. The antibacterial activity of the obtained C-dots was tested against and . The minimum bactericidal concentrations of the synthesized C-dots against and were 2 and 30 μg/mL, respectively, which are lower than that of previously reported C-dots. The antibacterial mechanism was investigated, and the results indicated that a large number of -NH groups on the C-dots' surface enhanced their antibacterial activity. Besides, the C-dots exhibited negligible cytotoxicity.
在耐药性不断增加的领域中，发现高效抗菌材料至关重要。在此，我们通过一种简单的一步水热法合成了具有优异抗菌活性的碳点（C点）。在该方法中，对苯二胺不仅作为碳源，还作为锚定在所得C点上的官能团的来源。对所得C点针对[具体细菌1]和[具体细菌2]的抗菌活性进行了测试。合成的C点对[具体细菌1]和[具体细菌2]的最低杀菌浓度分别为2和30μg/mL，低于先前报道的C点。对抗菌机制进行了研究，结果表明C点表面大量的-NH基团增强了它们的抗菌活性。此外，C点表现出可忽略不计的细胞毒性。
