School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, 2055 Yanan Street, Changchun, 130012, Jilin, People's Republic of China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, Jilin, People's Republic of China.
J Nanobiotechnology. 2022 Aug 11;20(1):368. doi: 10.1186/s12951-022-01572-w.
Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic CDs with antimicrobial activity have appeared. In the present work, we engineered a string of anionic CDs (especially CD31) as valid broad-spectrum bactericides to kill bacteria. Furthermore, CD31 conjugated with ɛ-polylysine (Plys) to construct injectable, and self-healing hydrogel (CD-Plys) that possess the advantages of remarkable broad spectrum antibacterial activity, excellent wound healing ability and satisfied biocompatibility. CD-Plys could dramatically accelerate wound healing with epithelization and enhanced angiogenesis. Taken together, this work provides a two-pronged strategy to explore CDs-based antimicrobial agents for disease therapy and tissue engineering.
开发高效的药物来消灭病原体和促进伤口愈合是非常重要的。尽管已经有一些阳离子碳点（CDs）被用于杀菌，但几乎没有出现具有抗菌活性的阴离子 CDs。在本工作中，我们设计了一系列阴离子 CDs（特别是 CD31）作为有效的广谱杀菌剂来杀死细菌。此外，将 CD31 与聚赖氨酸（Plys）结合构建可注射和自修复水凝胶（CD-Plys），该水凝胶具有显著的广谱抗菌活性、优异的伤口愈合能力和良好的生物相容性。CD-Plys 可以显著促进上皮化和增强血管生成，从而加速伤口愈合。总之，这项工作提供了一种双管齐下的策略，用于探索基于 CDs 的抗菌剂用于疾病治疗和组织工程。
