Zhao Linlu, Xing Yanlong, Wang Rui, Yu FeiFei, Yu Fabiao
Institute of Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, College of Pharmacy, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Clinical Medicine, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China.
ACS Appl Bio Mater. 2020 Jan 21;3(1):86-106. doi: 10.1021/acsabm.9b00843. Epub 2019 Dec 11.
Following the wisdom of nature to assemble functional candidates into exquisite nanoarchitectures is emerging as a promising field of research and has been widely applied in biomedical sciences. Owing to their excellent properties of structural controllability, functional diversity, dynamic adjustability, and prominent biocompatibility, the self-assembled nanoarchitectures come to play a pivotal role in fighting against cancer. This review outlines the most up-to-date developments in constructing phototherapeutic nanomaterials for photodynamic and photothermal therapy (PDT and PTT) of tumors, with emphasis on design ideas, building blocks, and advantageous characteristics of self-assembly. The prominent activities of cancer therapy obtained by these photoinduced nanotheranostics are also explored in-depth, together with the connections between the specific nanostructures and unique features, providing a comprehensive understanding of the self-assembled nanomaterials in improving the outcomes of PDT and PTT. This review aims to highlight the significance of self-assembled nanomaterials in enhancing phototherapeutic efficacy and to promote its development in various research interests ranging from material science and nanoscience to biomedicine and clinical medicine.
遵循自然智慧将功能性候选物组装成精致的纳米结构正成为一个有前途的研究领域，并已在生物医学科学中得到广泛应用。由于其具有结构可控性、功能多样性、动态可调性和突出的生物相容性等优异特性，自组装纳米结构在对抗癌症中发挥着关键作用。本综述概述了用于肿瘤光动力和光热疗法（PDT和PTT）的光治疗纳米材料构建方面的最新进展，重点介绍了自组装的设计理念、构建单元和优势特性。还深入探讨了这些光诱导纳米诊疗剂所获得的显著癌症治疗活性，以及特定纳米结构与独特特征之间的联系，全面了解自组装纳米材料在改善PDT和PTT疗效方面的作用。本综述旨在突出自组装纳米材料在提高光治疗效果方面的重要性，并促进其在从材料科学、纳米科学到生物医学和临床医学等各种研究领域的发展。
