Onwubalili J K, Edwards A J, Palmer L
Division of Communicable Disease, MRC Clinical Research Centre, Harrow, Middlesex.
Tubercle. 1987 Sep;68(3):195-200. doi: 10.1016/0041-3879(87)90055-9.
Lymphocyte subpopulations in vitro in 13 patients with bacteriologically-proven tuberculosis and 12 matched controls, by immunofluorescence using monoclonal antibodies have been studied. Active tuberculosis was associated with significant reductions in absolute numbers of total T (Leu 4 or 1+), T4 (Leu 3a+) and B (Leu 12+) lymphocytes, but there were no significant differences in total T8 (Leu 2a+) counts. In two patients, T4-lymphopenia was sufficiently profound to cause reversal of T4: T8 ratio (less than 1.2). These changes were not related to the radiological extent of the disease or size of the Mantoux reaction. Normal ranges for the different classes of lymphocytes were readily restored by chemotherapy.
通过使用单克隆抗体的免疫荧光法，对13例经细菌学证实的肺结核患者及12例匹配对照者的淋巴细胞亚群进行了体外研究。活动性肺结核与总T（Leu 4或1+）、T4（Leu 3a+）和B（Leu 12+）淋巴细胞绝对数量的显著减少相关，但总T8（Leu 2a+）计数无显著差异。在两名患者中，T4淋巴细胞减少足够严重，导致T4:T8比值逆转（小于1.2）。这些变化与疾病的放射学范围或结核菌素反应大小无关。不同类淋巴细胞的正常范围通过化疗很容易恢复。
