Cheng P N, Shiu W C, Tsao S Y, O S K
Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Clin Otolaryngol Allied Sci. 1989 Feb;14(1):53-9. doi: 10.1111/j.1365-2273.1989.tb00337.x.
The peripheral blood lymphocyte counts of 333 patients with a nasopharyngeal carcinoma and 125 control subjects were compared. The mean pretreatment lymphocyte count in the patients was significantly lower than that of the normal controls (P less than 0.0001). Subgroup analysis of absolute lymphocyte counts in different stages of the disease revealed a stage dependent lymphopenia which became significant when the disease was stage III or over (P less than 0.001). Characterization of peripheral blood lymphocyte subsets in 81 patients and 46 normal control subjects revealed a significant reduction of the absolute Pan T (T11) lymphocytes in the patients (P less than 0.0001). Both the absolute numbers of T helper (T4) and suppressor cells (T8) were reduced in the patients (P less than 0.0001 and less than 0.026, respectively). While the percentage of T4 was reduced (P less than 0.0001), the percentage of T8 was elevated (P less than 0.02), resulting in a reduced T4/T8 ratio (P less than 0.0001). The mean absolute and percentage counts of T11, T8 and B did not correlate with different stages of the disease.
比较了333例鼻咽癌患者和125例对照者的外周血淋巴细胞计数。患者治疗前淋巴细胞计数的平均值显著低于正常对照组（P<0.0001）。对疾病不同阶段的绝对淋巴细胞计数进行亚组分析显示，存在与分期相关的淋巴细胞减少，当疾病处于III期或更晚期时变得显著（P<0.001）。对81例患者和46例正常对照者的外周血淋巴细胞亚群进行特征分析显示，患者的绝对全T（T11）淋巴细胞显著减少（P<0.0001）。患者的辅助性T细胞（T4）和抑制性T细胞（T8）的绝对数量均减少（分别为P<0.0001和<0.026）。虽然T4百分比降低（P<0.0001），但T8百分比升高（P<0.02），导致T4/T8比值降低（P<0.0001）。T11、T8和B细胞的平均绝对计数和百分比计数与疾病的不同阶段无关。
