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大鼠牛血清白蛋白慢性血清病肾病

Bovine serum albumin chronic serum sickness nephropathy in rats.

作者信息

Bolton W K, Sturgill B C

出版信息

Br J Exp Pathol. 1978 Apr;59(2):167-77.

PMID:350256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041334/
Abstract

We administered bovine serum albumin (BSA) 1 or 3 mg i.v. into hyper-immune Sprague-Dawley rats weekly for up to 6 months. Animals with free circulating antibody 1 h after BSA developed mesangial deposits of IgG and C-3 without proteinuria. Rats without free antibody at 1 h developed either mesangial or mesangial and glomerular basement membrane (GBM) deposits. Rats given 3 mg BSA tended to have GBM deposits, proteinuria and undetectable antibody at 1 h. By electronmicroscopy, all rats had mesangial and subendothelial dense deposits, while those with GBM lesions had intramembranous and subepithelial deposits with foot process obliteration. Light microscopic evaluation of kidney tissue revealed only mild histological changes similar to those in age-matched control rats. The present studies demonstrate that prolonged i.v. administration of BSA into rats results in the development of a chronic non-inflammatory nephropathy. Despite certain parallels to chronic serum sickness nephropathy in rabbits, species differences appear to modify the nephropathy in rats.

摘要

我们每周一次静脉注射1毫克或3毫克牛血清白蛋白（BSA）至超免疫斯普拉格-道利大鼠体内，持续长达6个月。注射BSA后1小时有游离循环抗体的动物出现IgG和C-3的系膜沉积物，但无蛋白尿。1小时时无游离抗体的大鼠出现系膜或系膜及肾小球基底膜（GBM）沉积物。给予3毫克BSA的大鼠在1小时时倾向于出现GBM沉积物、蛋白尿且抗体检测不到。通过电子显微镜检查，所有大鼠均有系膜和内皮下致密沉积物，而有GBM病变的大鼠有膜内和上皮下沉积物，足突消失。肾脏组织的光镜评估仅显示出与年龄匹配的对照大鼠相似的轻度组织学变化。目前的研究表明，对大鼠长期静脉注射BSA会导致慢性非炎性肾病的发生。尽管与兔慢性血清病肾病有某些相似之处，但物种差异似乎改变了大鼠的肾病情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/d1b8c377f236/brjexppathol00128-0066-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/59a9bfcf76ca/brjexppathol00128-0064-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/8819a915df78/brjexppathol00128-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/ad6140f1ff1f/brjexppathol00128-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/d1b8c377f236/brjexppathol00128-0066-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/59a9bfcf76ca/brjexppathol00128-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/d4396d413db6/brjexppathol00128-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/6e4aede41007/brjexppathol00128-0064-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/ad4dfb510064/brjexppathol00128-0064-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/8819a915df78/brjexppathol00128-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/ad6140f1ff1f/brjexppathol00128-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c865/2041334/d1b8c377f236/brjexppathol00128-0066-c.jpg

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1
Bovine serum albumin chronic serum sickness nephropathy in rats.大鼠牛血清白蛋白慢性血清病肾病
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引用本文的文献

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Histochem J. 1993 May;25(5):367-75. doi: 10.1007/BF00159501.
2
Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. II. Ultrastructural studies.衰老的斯普拉格-道利大鼠的自发性肾小球硬化。II. 超微结构研究。
Am J Pathol. 1980 Feb;98(2):339-56.
3
Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane.

本文引用的文献

1
STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. II. PATHOGENETIC AND PHARMACODYNAMIC STUDIES.循环中抗原 - 抗体复合物及其他大分子在血管内定位的研究。II. 发病机制与药效学研究。
J Exp Med. 1963 Oct 1;118(4):503-13. doi: 10.1084/jem.118.4.503.
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A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY.一种制备荧光抗体的透析技术。
Virology. 1963 Aug;20:642-4. doi: 10.1016/0042-6822(63)90292-7.
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The pathologic effects of intravenously administered soluble antigen-antibody complexes. I. Passive serum sickness in mice.
大鼠血清病：炎症介质在免疫复合物于肾小球基底膜沉积过程中可能发挥的作用。
Clin Exp Immunol. 1982 Sep;49(3):631-8.
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New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens.与细胞免疫介导相符的新型实验性肾小球肾炎禽类模型。鸡的非体液介导性肾小球肾炎。
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Bovine serum albumin (BSA) nephritis in rats. III. Antigen distribution in various organs.大鼠牛血清白蛋白（BSA）肾炎。III. 抗原在各器官中的分布。
Clin Exp Immunol. 1985 Feb;59(2):293-9.
6
Three-dimensional ultrastructure of glomerular injury in serum sickness nephritis using the quick-freezing and deep-etching method.采用快速冷冻和深度蚀刻法观察血清病肾炎肾小球损伤的三维超微结构。
Virchows Arch A Pathol Anat Histopathol. 1991;418(3):185-92. doi: 10.1007/BF01606055.
静脉注射可溶性抗原 - 抗体复合物的病理效应。I. 小鼠被动血清病
J Exp Med. 1960 Feb 1;111(2):181-94. doi: 10.1084/jem.111.2.181.
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Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis.实验性肾小球肾炎。一种类似于人类肾小球肾炎谱系的实验室模型的发病机制。
J Exp Med. 1961 May 1;113(5):899-920. doi: 10.1084/jem.113.5.899.
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The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species.不同物种血小板和多形核白细胞中的组胺和血清素含量。
J Physiol. 1954 May 28;124(2):305-10. doi: 10.1113/jphysiol.1954.sp005109.
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Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.网状内皮系统粒细胞吞噬活性的定量研究。II. 网状内皮系统动力学与注入碳剂量的关系；器官重量与其活性之间的关系。
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Experimental glomerulonephritis in rats.
Lab Invest. 1967 Nov;17(5):481-8.
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Immune complex disease. II. The role of circulatory dynamics and glomerular filtration in the development of experimental glomerulonephritis.免疫复合物疾病。II. 循环动力学和肾小球滤过在实验性肾小球肾炎发展中的作用。
Johns Hopkins Med J. 1967 Apr;120(4):252-61.
9
Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation.抗原-抗体复合物的研究。I. 兔循环系统中可溶性复合物的清除
J Exp Med. 1971 Apr 1;133(4):713-39. doi: 10.1084/jem.133.4.713.
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Johns Hopkins Med J. 1972 Jun;130(6):344-57.