Gorbach A D, Novikov D K, Gorbach I N
Biull Eksp Biol Med. 1978 Apr;85(4):457-60.
The blood serum of patients with active tuberculosis of the lungs and chronic pneumonia inhibited migration of donor's leukocytes and macrophages of the peritonal exudate of guinea pigs when compared with migration of similar cells in the medium with the serum of cattle or donors. After chromatography these sera were fractionated on the columns with Sephadex G-100. Fractions containing the leukocyte migration inhibition factor (LMIF) suppressed, up to complete abolition, the intradermal reaction to tuberculin in man and guinea pigs sensitized with BCG. The LMIF is supposed to act in the regulation of delayed hypersensitivity reaction.
与含有牛血清或供体血清的培养基中类似细胞的迁移相比，活动性肺结核和慢性肺炎患者的血清抑制了豚鼠腹腔渗出液中供体白细胞和巨噬细胞的迁移。经色谱分析后，这些血清在装有葡聚糖G - 100的柱上进行分级分离。含有白细胞迁移抑制因子（LMIF）的级分可抑制直至完全消除用卡介苗致敏的人和豚鼠对结核菌素的皮内反应。推测LMIF在迟发型超敏反应的调节中起作用。
