Novikov D K, Shmakov A P, Borisenko I D
Biull Eksp Biol Med. 1978 Nov;86(11):568-72.
Blood serum of patients suffering from cancer of the stomach and urinary bladder inhibited in vitro migration of autologous leukocytes, leukocytes of donors and control patients, and also guinea pig macrophages in over half of cases. In chromatography of these sera on Sephadex G-100 the activity inhibiting the leukocyte migration was revealed in fraction I (Mol. wt. over 100000) and in fractions IV and V (Mol. wt under 30 000). The blood serum and its fractions from cancer patients failed to eliminate the leukocyte migration inhibition caused by the tumour antigens in comparison with the leukocyte migration in the medium with control serum without any antigens. As suggested, the activity of fraction I inhibiting the leukocyte migration was due to the antigen-antibody complex, and of fraction IV and V--to a factor similar by its properties to the factor produced in vitro by lymphocytes stimulated by the antigens or mitogens.
胃癌和膀胱癌患者的血清在超过半数的病例中，可在体外抑制自体白细胞、供体白细胞以及对照患者白细胞的迁移，还能抑制豚鼠巨噬细胞的迁移。用葡聚糖凝胶G - 100对这些血清进行层析时，在组分I（分子量超过100000）以及组分IV和V（分子量低于30000）中发现了抑制白细胞迁移的活性。与不含任何抗原的对照血清培养基中的白细胞迁移相比，癌症患者的血清及其组分未能消除肿瘤抗原引起的白细胞迁移抑制。据推测，组分I抑制白细胞迁移的活性归因于抗原 - 抗体复合物，而组分IV和V的活性则归因于一种性质类似于抗原或有丝分裂原刺激的淋巴细胞在体外产生的因子的物质。
