Sun Zhi-Gang, Li Zhi-Na, Zhang Jin-Mai, Hou Xiao-Yan, Yeh Stacy Mary, Ming Xin
Central Laboratory, Linyi Central Hospital, No.17 Jiankang Road, Linyi 276400, China.
Departments of Cancer Biology and Biomedical Engineering, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Curr Top Med Chem. 2022 Mar 4;22(4):305-329. doi: 10.2174/1568026622666220117111858.
Flavonoids, a series of compounds with a C6-C3-C6 structure, mostly originate from plant metabolism. Flavonoids have shown beneficial effects on many aspects of human physiology and health. Recently, many flavonoids with various activities have been discovered, which has led to more and more studies focusing on their physiological and pharmacodynamic activities. The anticancer and anti-viral activities especially have gained the attention of many researchers. Therefore, the discovery and development of flavonoids as anti-disease drugs has great potential and may make a significant contribution to fighting diseases. This review focus on the discovery and development of flavonoids in medicinal chemistry in recent years.
黄酮类化合物是一系列具有C6-C3-C6结构的化合物，大多源自植物代谢。黄酮类化合物已在人体生理和健康的许多方面显示出有益作用。最近，发现了许多具有各种活性的黄酮类化合物，这使得越来越多的研究聚焦于它们的生理和药效学活性。尤其是其抗癌和抗病毒活性已引起许多研究人员的关注。因此，将黄酮类化合物开发为抗病药物具有巨大潜力，可能会为抗击疾病做出重大贡献。本综述聚焦于近年来黄酮类化合物在药物化学中的发现与开发。
