Meng Keyu, Xiao Xiao, Wei Wenxin, Chen Guorui, Nashalian Ardo, Shen Sophia, Xiao Xiao, Chen Jun
School of Electronic and Information Engineering Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, Changchun University, Changchun, 130022, China.
Department of Bioengineering, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Adv Mater. 2022 May;34(21):e2109357. doi: 10.1002/adma.202109357. Epub 2022 Mar 31.
Cardiovascular diseases remain the leading cause of death worldwide. The rapid development of flexible sensing technologies and wearable pressure sensors have attracted keen research interest and have been widely used for long-term and real-time cardiovascular status monitoring. Owing to compelling characteristics, including light weight, wearing comfort, and high sensitivity to pulse pressures, physiological pulse waveforms can be precisely and continuously monitored by flexible pressure sensors for wearable health monitoring. Herein, an overview of wearable pressure sensors for human pulse wave monitoring is presented, with a focus on the transduction mechanism, microengineering structures, and related applications in pulse wave monitoring and cardiovascular condition assessment. The conceptualizations and methods for the acquisition of physiological and pathological information related to the cardiovascular system are outlined. The biomechanics of arterial pulse waves and the working mechanism of various wearable pressure sensors, including triboelectric, piezoelectric, magnetoelastic, piezoresistive, capacitive, and optical sensors, are also subject to systematic debate. Exemple applications of pulse wave measurement based on microengineering structured devices are then summarized. Finally, a discussion of the opportunities and challenges that wearable pressure sensors face, as well as their potential as a wearable intelligent system for personalized healthcare is given in conclusion.
心血管疾病仍然是全球主要死因。柔性传感技术和可穿戴压力传感器的快速发展引起了浓厚的研究兴趣，并已广泛用于长期和实时心血管状态监测。由于具有重量轻、佩戴舒适以及对脉压敏感度高等引人注目的特性，柔性压力传感器可精确且连续地监测生理脉搏波形，用于可穿戴健康监测。本文对用于人体脉搏波监测的可穿戴压力传感器进行了综述，重点介绍了其转换机制、微工程结构以及在脉搏波监测和心血管状况评估中的相关应用。概述了获取与心血管系统相关的生理和病理信息的概念和方法。还对动脉脉搏波的生物力学以及各种可穿戴压力传感器（包括摩擦电、压电、磁弹性、压阻、电容和光学传感器）的工作机制进行了系统讨论。然后总结了基于微工程结构器件的脉搏波测量的示例应用。最后，讨论了可穿戴压力传感器面临的机遇和挑战，以及其作为个性化医疗可穿戴智能系统的潜力。
