Feng Pei, Jia Jiye, Peng Shuping, Shuai Yang, Pan Hao, Bai Xinna, Shuai Cijun
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China.
NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
Biomater Res. 2022 Jan 20;26(1):2. doi: 10.1186/s40824-021-00248-0.
The reinforcement effect of fiber-reinforced polymer composites is usually limited because of the poor interfacial interaction between fiber and polymer, though fiber reinforcement is regarded as an effective method to enhance the mechanical properties of polymer.
In this study, nano-SiO particles grafted by 3-Glycidoxypropyltrimethoxysilane (KH560) were introduced onto the surface of 3-Aminopropyltriethoxysilane (KH550) modified carbon fiber (CF) by a self-assembly strategy to improve the interfacial bonding between CF and biopolymer poly (lactic acid) (PLLA).
The results indicated that PLLA chains preferred to anchor at the surface of nano-SiO particles and then formed high order crystalline structures. Subsequently, PLLA spherulites could epitaxially grow on the surface of functionalized CF, forming a transcrystalline structure at the CF/PLLA interface. Meanwhile, the nano-SiO particles were fixed in the transcrystalline structure, which induced a stronger mechanical locking effect between CF and PLLA matrix. The results of tensile experiments indicated that the PLLA/CF-SiO scaffold with a ratio of CF to SiO of 9:3 possessed the optimal strength and modulus of 10.11 MPa and 1.18 GPa, respectively. In addition, in vitro tests including cell adhesion and fluorescence indicated that the scaffold had no toxicity and could provide a suitable microenvironment for the growth and proliferation of cell.
In short, the PLLA/CF-SiO scaffold with good mechanical properties and cytocompatibility had great potential in the application of bone tissue engineering.
尽管纤维增强被认为是增强聚合物机械性能的有效方法，但由于纤维与聚合物之间的界面相互作用较差，纤维增强聚合物复合材料的增强效果通常有限。
在本研究中，通过自组装策略将经3-缩水甘油氧基丙基三甲氧基硅烷（KH560）接枝的纳米SiO₂颗粒引入到经3-氨丙基三乙氧基硅烷（KH550）改性的碳纤维（CF）表面，以改善CF与生物聚合物聚乳酸（PLLA）之间的界面结合。
结果表明，PLLA链倾向于锚定在纳米SiO₂颗粒表面，然后形成高阶晶体结构。随后，PLLA球晶可以在功能化CF表面外延生长，在CF/PLLA界面形成穿晶结构。同时，纳米SiO₂颗粒固定在穿晶结构中，这在CF和PLLA基体之间产生了更强的机械锁定效应。拉伸实验结果表明，CF与SiO₂比例为9:3的PLLA/CF-SiO₂支架具有最佳强度和模量，分别为10.11MPa和1.18GPa。此外，包括细胞黏附和荧光在内的体外测试表明，该支架无毒性，可为细胞的生长和增殖提供合适的微环境。
简而言之，具有良好机械性能和细胞相容性的PLLA/CF-SiO₂支架在骨组织工程应用中具有巨大潜力。
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