State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China; Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
J Adv Res. 2023 Jun;48:175-190. doi: 10.1016/j.jare.2022.08.017. Epub 2022 Sep 7.
The aggregation of graphene oxide (GO) is considered as main challenge, although GO possesses excellent mechanical properties which arouses widespread attention as reinforcement for polymers.
In this study, silicon dioxide (SiO) nanoparticles were decorated onto surface of GO nanosheets through in situ growth method for promoting dispersion of GO in poly(l-lactic acid) (PLLA) bone scaffold.
Hydroxyl and carboxyl functional groups of GO provided sites for SiO nucleation, and SiO grew with hydrolysis and polycondensation of tetraethyl orthosilicate (TEOS) and finally formed nanoparticles onto surface of GO with covalent bonds. Then, the GO@ SiO nanocomposite was blended with PLLA for the fabrication of bone scaffold by selective laser sintering (SLS).
The results indicated that the obtained SiO were distributed relatively uniformly on surface of GO under TEOS concentration of 0.10 mol/L (GO@SiO-10), and the covering of SiO on GO could increase interlayer distance of GO nanosheets from 0.799 nm to 0.894 nm, thus reducing van der Waals forces between GO nanosheets and facilitating the dispersion. Tensile and compressive strength of scaffold containing GO@SiO hybrids were significantly enhanced, especially for the scaffold containing GO@SiO-10 hybrids with enhancement of 30.95 % in tensile strength and 66.33 % in compressive strength compared with the scaffold containing GO. Additionally, cell adhesion and fluorescence experiments demonstrated excellent cytocompatibility of the scaffold.
The good dispersion of GO@SiO enhances the mechanical properties and cytocompatibility of scaffold, making it a potential candidate for bone tissue engineering applications.
氧化石墨烯（GO）的聚集被认为是主要挑战，尽管 GO 具有出色的机械性能，作为聚合物的增强材料引起了广泛关注。
本研究通过原位生长法在 GO 纳米片表面修饰二氧化硅（SiO）纳米颗粒，以促进 GO 在聚（L-乳酸）（PLLA）骨支架中的分散。
GO 的羟基和羧基官能团为 SiO 成核提供了位点，SiO 通过正硅酸乙酯（TEOS）的水解和缩聚生长，最终通过共价键在 GO 表面形成纳米颗粒。然后，将 GO@SiO 纳米复合材料与 PLLA 混合，通过选择性激光烧结（SLS）制备骨支架。
结果表明，在 TEOS 浓度为 0.10 mol/L（GO@SiO-10）下，获得的 SiO 相对均匀地分布在 GO 表面，SiO 的覆盖可以增加 GO 纳米片的层间距从 0.799nm 增加到 0.894nm，从而减少 GO 纳米片之间的范德华力，促进分散。含有 GO@SiO 杂化物的支架的拉伸和压缩强度显著提高，特别是含有 GO@SiO-10 杂化物的支架，其拉伸强度提高了 30.95%，压缩强度提高了 66.33%，与含有 GO 的支架相比。此外，细胞粘附和荧光实验证明了支架具有良好的细胞相容性。
GO@SiO 的良好分散性提高了支架的机械性能和细胞相容性，使其成为骨组织工程应用的潜在候选材料。
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