The University of Western Australia, Oral Health Centre of Western Australia, Dental School, Nedlands, WA, 6009, Australia.
NK Perio & Implants, Specialist Private Practice, Suite 41, 11, Preston Street, Como, WA, 6152, Australia.
Clin Oral Investig. 2022 Mar;26(3):2317-2334. doi: 10.1007/s00784-021-04343-3. Epub 2022 Jan 23.
To investigate the global prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans (Aa).
A comprehensive electronic search of databases, PUBMED, MEDLINE, EMBASE, BIOSIS, and SCOPUS, was conducted up to August 2021. All published articles and studies were considered, excluding animal studies, editorials, personal opinions, letters to editor, conference abstracts, posters, and those studies without full text. The primary objective of this systematic review was to determine the presence of the JP2 genotype of Aa in the world population.
A total of 295 articles were identified, of which 62 were preselected, and 51 were finally included in this review. Due to variable study designs and high heterogeneity, a meta-analysis was not conducted. A total of 9744 subjects were screened for the presence of the JP2 genotype of Aa worldwide, and only 621 cases were found positive.
A relatively high presence of JP2 genotype of Aa was found in subjects from South America, North America, and Africa. There were no studies estimating the presence of the JP2 genotype of Aa in the Oceania region. The heterogeneity and quality of the included publications suggest that caution should be exercised when interpreting the data and that there remains an important need for additional evidence.
Periodontitis is a highly prevalent inflammatory oral disorder with substantial aesthetic, functional, and psychological implications for patients. The JP2 genotype of Aa is implicated in the pathogenesis of periodontitis. To the best of our knowledge, there is a lack of systematic reviews estimating the presence of the JP2 genotype of Aa in the global population. We identified a relatively high presence of the JP2 genotype of Aa in specific geographic areas of the world, and we propose that cross-sectional and longitudinal studies are lacking in the Oceania region and need to be conducted to estimate the presence of the JP2 genotype of Aa in this region.
调查导致放线共生放线杆菌（Aa）的 JP2 基因型在全球的流行情况。
对数据库（PUBMED、MEDLINE、EMBASE、BIOSIS 和 SCOPUS）进行全面的电子检索，检索时间截至 2021 年 8 月。考虑了所有已发表的文章和研究，不包括动物研究、社论、个人意见、给编辑的信、会议摘要、海报以及那些没有全文的研究。本系统评价的主要目的是确定世界人群中 Aa 的 JP2 基因型的存在情况。
共确定了 295 篇文章，其中预筛选了 62 篇，最后纳入了 51 篇综述。由于研究设计不同且存在高度异质性，因此未进行荟萃分析。全球共筛查了 9744 名受试者是否存在 Aa 的 JP2 基因型，仅发现 621 例阳性。
在来自南美洲、北美洲和非洲的受试者中发现了相对较高的 Aa JP2 基因型的存在。在大洋洲地区，没有研究估计 Aa JP2 基因型的存在情况。纳入的出版物的异质性和质量表明，在解释数据时应谨慎，并仍然需要更多的证据。
牙周炎是一种高度流行的炎症性口腔疾病，对患者的美观、功能和心理有很大的影响。Aa 的 JP2 基因型与牙周炎的发病机制有关。据我们所知，目前还没有系统评价估计全球人群中 Aa JP2 基因型的存在情况。我们发现，在世界特定的地理区域，Aa 的 JP2 基因型存在相对较高的情况，我们建议大洋洲地区缺乏横断面和纵向研究，需要进行这些研究以估计该地区 Aa JP2 基因型的存在情况。
