Makke Alaa
Oral and Maxillofacial Department, Umm AlQura University, Faculty of Dentistry, Makkah 24225, Saudi Arabia.
Int J Dent. 2022 Jan 12;2022:2845902. doi: 10.1155/2022/2845902. eCollection 2022.
Many factors play a significant role in osseointegration and healing after dental implant insertion and restoration. Some factors are related to dental biomaterials, such as the dental implant, prosthesis, and grafting materials. Other factors can be connected to operator skills and accumulated experience. Local and systemic patient-related factors are crucial in determining the success of the dental implant. Thorough examination and analysis of local factors using available examination tools are vital to prepare the implant candidate for such treatment. The patient's systemic condition directly affects the healing of the dental implant. One of the most overlooked systemic factors is the patients' vitamin level, which influences bone formation around the implant and subsequent osseointegration. The current review examined the available literature regarding the association between vitamin supplementation and dental implant osseointegration.
Data of this review were derived from recent research available on PubMed, Google Scholar, and Scopus. Inclusion criteria were the relation between the vitamin serum and dental implant osseointegration or failure. The Systematic Reviews and Meta-Analyses (PRISMA) checklist was followed to perform the review. The study's outcome was the need for vitamin supplementation to prevent implant failure.
Five human studies (including case reports, case series, and retrospective studies) and six animal studies. All included studies discussed the relationship between vitamin , early dental implant failure, and bone implant contact. Three retrospective studies found no significant relationship between vitamin supplementation and EDIFs in humans. On the other hand, one retrospective study showed a significant relationship in humans. A case report and case series claimed that the implant was successfully placed after vitamin supplementation. A total of four animal studies showed a significant relationship between vitamin supplementation and osseointegration of the dental implant. Two animal studies showed no significant association.
To ensure optimal treatment outcomes, it is recommended to supplement the patient with vitamin if the serum level is not within the normal range. Further clinical studies and case reports are needed to confirm the association between serum vitamin levels and osseointegration.
许多因素在牙种植体植入和修复后的骨整合及愈合过程中起着重要作用。一些因素与牙科生物材料有关，如牙种植体、修复体和移植材料。其他因素则与操作者的技能和积累的经验有关。局部和全身的患者相关因素对于确定牙种植体的成功与否至关重要。使用可用的检查工具对局部因素进行全面检查和分析对于为这种治疗准备种植候选者至关重要。患者的全身状况直接影响牙种植体的愈合。最容易被忽视的全身因素之一是患者的维生素水平，它会影响种植体周围的骨形成以及随后的骨整合。本综述研究了关于维生素补充与牙种植体骨整合之间关联的现有文献。
本综述的数据来源于PubMed、谷歌学术和Scopus上的近期研究。纳入标准是维生素血清水平与牙种植体骨整合或失败之间的关系。遵循系统评价和Meta分析（PRISMA）清单进行综述。该研究的结果是预防种植体失败所需的维生素补充。
五项人体研究（包括病例报告、病例系列和回顾性研究）和六项动物研究。所有纳入研究都讨论了维生素、早期牙种植体失败和骨种植体接触之间的关系。三项回顾性研究发现维生素补充与人类早期牙种植体失败之间无显著关系。另一方面，一项回顾性研究表明在人类中存在显著关系。一份病例报告和病例系列称在补充维生素后种植体成功植入。共有四项动物研究表明维生素补充与牙种植体骨整合之间存在显著关系。两项动物研究表明无显著关联。
为确保获得最佳治疗效果，建议在血清水平不在正常范围内时为患者补充维生素。需要进一步的临床研究和病例报告来证实血清维生素水平与骨整合之间的关联。
