Emerg Infect Dis. 2022 Feb;28(2):440-444. doi: 10.3201/eid2802.211725.
Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.
柬埔寨大湄公河次区域的居民接触到的病原体可能会影响与严重急性呼吸综合征冠状病毒 2 型的血清交叉反应性。在大流行前对 528 名疟疾病例进行的血清学调查显示,针对刺突和受体结合域抗原的非中和 IgG 的阳性率高于预期。这些发现可能会影响对大规模血清学调查的解释。